The Relationship Between CYP3A7~*1C Polymorphisms And Bone Mineral Density In Menopausal Mongol Women

Objective To explore the relationship between CYP3A7 * 1C polymorphisms and bone mineral density in menopausal mongolia women in Inner Mongolia.Methods CYP3A7 polymorphisms was defined by the SspI restriction enzyme using polymerase chain reaction- restriction fragment length polymorphism in 185 healthy menopausal mongolia women in Inner Mongolia,forearm BMD were measured by dual energy X - ray absorptiometry.Results The frequency distribution of CYP3A7 genotype in normal group was:TT84.3%,TG15. 0%,GG0.7%;Osteoporosis group:TT71.1%,TG26.3%,GG2.6%.CYP3A7 allele frequency in normal group were:T 91.8%,G 8.2%;Osteoporosis group:T 84.2%,G 15. 8%,Covariance analysis showed significant association between CYP3A7 genotype and BMD at forearm in all groups.There was statistical significant between osteopenia group and normal bone mass group in allele genes.Conclusions Among Mongol women in Inner Mongolia, CYP3A7 polymorphisms was associated with bone mineral density(P＜0.05).It can be used to predict the risk of osteoporosis.