Clinical Analysis Of 5 Patients With Pseudohypoparathyroidism

ObjectivesTo investigate the clinical data of patients with pseudohypoparathyroidism(PHP).MethodsTotally 5 patients with pseudo-hypoparathyroidism who were hospitalized in the 2nd Afiliated Hospital of Zhejiang University from January 1995 to March 2009 were enrolled in this study.The clinical datas including manifestation,objective findings and etiology tests,diagnosis and misdiagnosis,treatment from all the patients were analyzed retrospectively.ResultsPseudohypoparathyroidism(PHP) is a rare genetic deficient disease.The nature of PHP is a lack of response to the parathormone(PTH) of its effector organs,such as kidney,bone,with features of Albright osteodystrophy hereditary osteodystrophy(AHO),tetany,epilepsy,hypocalcaemia,hyperphosphatemia, intracranial symmetri-cal calcification. ConclusionPseudohypoparathyroidism is a poradic disease.PHP is a complex disorder with inter- and intrafamilial variability in the dysfunction of the parathyroid and other cAMP-dependent hormones,and have high rate misdiagnosis of initial diagnosis,to the repeatedly tetany,the badly medicinal control of the epilepsy,Albright osteodystrophy hereditary osteodystrophy should test the serum calcium,serum phosphorus,serum PTH and cranial CT scan as soon as possible.It is a hereditary disease,and has no special method of treatment at present.The acute attack often uses calglucon intravenous to control the twitches the outbreak positively.The non-acute attack need the long-term treatment,and supply the calcium,Vitamin D2 or AT-10 and take few food which contain high phosphorus in order to alleviate the symptom and prevent the further progress of conditions.