| Objective To determine the type of Th cell immune responses of systemic fungal infection and the relationship between cytokine and organ histopathological changes.Methods A murine model of systematic Candidiasis was established by injection with Candida albicans (C. albicans)via the tail vein.. Organ fungal burden were determined with the plating dilution method. Sections of internal organs were made and stained by HE & PAS staining. Histopathological changes were inspected. Cytokines (IFN-γand IL-4) induced by Con-A in splenic lymphocyte and IL-6 from kidney tissues were detected by ELISA (Enzyme–linked immunosorbebt assay).Results Fungal colony counts in the kidney progressively increased during fatal infection and decreased during nonfatal infection. The hypha of C. albicans was obvious in the kidney. The histopathological damage was serious. In contrast, the colony counts in spleen or liver progressively declined in all mice and the histopathological changes were not obvious. Induced splenic IFN–γdecreased, while IL-4 increased sharply during fatal or nonfatal infection. In nonfatal infection group, IL-6 of kidney presented a tendency of increasing. While in fatal infection group it presented a tendency of increasing and decreasing respectively during earlier and later period.Conclusion There are susceptivity differences of different organs in systematic infection of C. albicans. It indicates a Th2 type in systemic candidiasis. IL-6 may play bidirectional roles during the period of candidiasis nephritis formation and development.
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