The Treatment Of Lupus Nephritis & The Influence Of Serum/urine Macrophage Migration Inhibitory Factor By Promoting Blood Flow And Deficiency Of Kidney

Lupus nephritis is one of the immune multiple nephritis during systemic lupus erythematosus. Chinese Medicine treatment is good at postpones the state of LN, avoid relapse, and keep long time stabilization, so that could help to reduce the dosage of hormone. As a pro-inflammatory cytokine, Macrophage migration inhibitory factor (MIF) causes the aggregation, accrementition, activation and excretion of megalophage when it accumulates to a superfluous amount at kidney. MIF plays a very important role with LN and becomes more and more popular in the field of lupus nephritis research.Object: to discuss the curative effect and mechanism action of lupus nephritis(LN) by using Chinese traditional medicine to promoting blood flow and deficiency of kidney(radices rehmanniae,radices rubiae,radices paeoniae rubra,cortex moutan,radices scrophulariae,radices salviae miltiorrhizae,Ligusticum wallichii,herba artemisiae chinghao,Oldenlandia diffusa,Duchesnea indica Fock,Herba Scutellariae Barbatae), and its influence to the status of human Serum/Urine macrophage migration inhibitory factor(MIF).Methods: select 39 LN patients randomly into 2 groups. Group A with 20 patients is treated by integrated traditional and western medicine to promoting blood flow and with hormone therapy. Group B with 19 patients is treated by western medicine with hormone therapy. Inspect the changing status of Serum/Urine MIF(use ELISA), urinary total protein(UTP), white blood cell count(WBC), hemoglobin(HB), platelet count(PLT), erythrocyte sedimentation rate (ESR), immunoglobulin G(IgG), complement 3(C3), antinuclear antibody(ANA), as well as the activity index of Lupus and the dosage of hormone before and after the therapy.Result: the curative effect of Group A - treated by integrated traditional and western medicine is averagely better than Group B– treated by western medicine(P<0.05). The status of Serum/Urine MIF keeps in high level. Before the treatment the status of Serum/Urine MIF varies inversely with C3(r=-0.36, P<0.05; r=-0.19, P<0.05), varies directly with IgG(r=0.37, P<0.01; r=0.42, P<0.01), the activity index of Lupus(r=0.598, P<0.01; r=0.641, P<0.01) and UTP(r=0.524, P<0.01; r=0.749, P<0.01). The index of Serum MIF decreases little after the therapy. In Group A, the index of Urine MIF(P<0.05), activity index of Lupus(P<0.05), WBC(P<0.05), HB(P<0.05), PLT(P<0.01), ESR(P<0.01), IgG(P<0.05), C3(P<0.05) and the dosage of hormone(P<0.05)all have marked decrease than Group B. The titer of UTP and ANA has marked decrease in both groups(P<0.01) after the therapy with little difference.Conclusion: the method can be used to cure LN by the regulation of immunity, inhibit immunity inflammation, anti-infection and etc. It can control the Urine MIF and the activity index of Lupus of LN patient.