Sijunzi Decoction Affected On The Immune Function Of Premature Infants

Objective:To investigate the curative effects of Sijunzi decoction on immune function of the premature infants in spleen deficiency.And to quantitatively record the symptoms and signs according to certain criteria,and evaluate the efficacy and safety of Sijunzi decoction.Study the effect of Sijunzi decoction on immune function of premature infants.With a view to looking for safe, effective,cheap and simple ways to improve the clinical symptoms of deficiency in preterm infants,improve the ability of life in preterm infants,regulate immune function in children,reduce premature infants the incidence of hospital infections,improve quality of life in preterm infants to reduce the financial burden of home.Methods:According to the case study of prospective randomized controlled trial design of case study methods,were included in January 2008 -2009 month in March in Guangzhou University of Traditional Chinese Medicine subsidiary maternity Children's Hospital Neonatal Intensive Care Center,hospital 60 cases of premature infants,which were randomly divided into traditional Chinese medicine treatment group and control group two.Control group of premature infants according to management guidelines for premature infants with conventional treatment;Treatment group in the conventional management of premature infants at the same time,to oral Sijunzitang decoction of Chinese medicine,a small amount several times(1-3ml /times,Q3h-Q4h/times), received treatment for a total of two weeks.Deficiency were observed before and after treatment the clinical symptoms(loss of appetite,abdominal distension,diarrhea,edema,Tongue,fingerprints,milk,body weight decreased physiological days,weight gain,hospital infection,etc.). Detection of two groups before and after treatment of immune function (T-lymphocyte subsets:CD3,CD4,CD4/CD8;Immunoglobulinv:IgG,IgA,IgM), to carry out their own before and after the control and the control groups and statistical analysis.Result:After treatment,IgG before and after treatment were significantly different(P＜0.01),IgA before and after treatment were statistically significant differences(P＜0.05);After treatment,CD3,CD4,CD4/CD8 were significantly increased compared with before treatment,the difference was statistically significant(P＜0.05);The control group before and after treatment CD3,CD4,CD8,CD4/CD8,IgG,IgA,IgM by t test before and after the match,there was no significant difference(P＞0.05);Treatment group the incidence of hospital infection was 6.7%,control group,the incidence of hospital infection was 26.7%,the two groups were statistically significant differences(P＜0.05);Deficiency symptoms of the treatment group significant improvements in total efficiency of 50%,control group,markedly effective rate was 16.7%;Weight gain f treatment group is better than the control group's,the difference was statistically significant(P＜0.05).The premature infants are fed without adverse effects of Sijunzi decoction.Conclusion:By regulating the T-lymphocyte subsets and immunoglobulin, Sijunzi decoction in premature infants can regulate cellular immune function, enhance the body immunity,to reduce hospital infection;can also improve the deficiency of prematurity clinical symptoms,improve digestion significantly.