| Objective: To study the meaning of serum Retinal Binding Protein 4 of type 2 diabetes companied with diabetic retinopathy.Methods: Serum RBP4 and Transthyretin (TTR) of 35 patients with diabetic retinopathy were crosssectionally measured by enzyme linked immunosorbent assay (ELISA). 37 diabetic patients without diabetic retinopathy and 30 nondiabetic subjects were enrolled as controls.Results: Serum RBP4 level was significantly higher in patients with DR than that in controls (15.59±4.16mg/L vs 13.15±3.08mg/L, P<0.05),but there was no difference between patients with and without DR (15.59±4.16mg/L vs 15.09±3.15mg/L,P=0.073). However, the RBP4: TTR ratio was markedly increased in patients with DR than that in patients without DR and controls (0.118±0.063 vs 0.087±0.036 and 0.072±0.021, both P<0.05). In addition, RBP4 and the RBP4:TTR ratio were analyzed respectively according to Binary Logistic Backward, RBP(4 B=0.214 OR=1.239 P=0.022)and RBP4:TTR ratio( B=0.718 OR=2.051 P=0.018)were found to be the risk factors for diabetic retinopathy, and the RBP4:TTR ratio was more contributive than serum RBP4 concentration in type 2 diabetes companied with diabetic retinopathy.Conclusions: Serum RBP4 may be a novel risk factor for diabetic retinopathy of type 2 diabetes mellitus, and the RBP4/TTR ratio is more valuable than serum RBP4 concentration to evaluate risk factor of diabetic retinopathy. |
