Relation Between Nm23 Expression And The Invasion Metastasis Of Pancreatic Cancer

Objective: To elucidate the expression of nm23 gene in invasion and metastasis of pancreatic cancer , and evaluate its value for the diagnoses of pancreatic cancer.Methods:S-P immunohistochemica1 method was used to examine the expression of nm23/NDPK in 43 pancreatic cancer and 14 normal pancreas tissues.Result: Twenty - six of 43 (65.0%) pancreatic cancer showed strong immunoreactivity for NDPK ,whereas 4 of 14(28.6%) norma1 pancreatic tissues showed weak immunoreactivity.Si- gnificant difference was found between the two groups( P<0.05). The nm23/NDPK expression levels in pancreatic cancer of lower differentiation was higher than those in pancreatic cancer of higher differentiation(90.9%;P<005).Positive staining was associated with higher incidence of lymph node metastasis(10/14 71.4%)than negative staining(6/193 1.6%,P<0.05).These results suggested that nm23/NDPK expression was positively associated with lymph node metastasis and aggressiveness . Conclusion: nm23 / NDPK can serve as a marker for malignant potentiality and indicate the prognosis of pancreatic cancer.