| With the Plasma volume expansion in the treatment of preeclampsia-depth study of the application, and its characteristics in hemodynamics medical profession has been more and more recognized, but there are still some risks and limitations. Although there are some against the expansion of the academic treatment of the RCT experiment, for various reasons, some results are different. Therefore, an urgent need to academia a scientific and effective research methods, tests on the integration of these RCT to guide clinical treatment.Objective: The purpose of this paper through the Meta analysis method to the past, a number of independent, objective and true reflection of the treatment of pre-eclampsia expansion of randomized controlled trials of research findings, their cesarean section rate, prematurity rate, perinatal mortality , neonatal Apgar score <7, the ratio of the application of the drug need indicators such as the ratio of the combined analysis, expansion of treatment to evaluate the clinical efficacy for the treatment of patients with the choice of programs to provide reference for clinicians to provide evidence of the clinical decision-making.Methods: Systematic review of methods used to collect and published both at home and abroad have registered but not yet published in the expansion of the treatment of pre-eclampsia, select colloidal crystal expansion expansion of treatment and clinical study of randomized controlled trials Meta analysis of literature. All research group are to expand the test group to non-expansion group, the control group. The development of strict inclusion and exclusion criteria. To Pre-eclampsia, pregnance induced hypertasion, volume expansion, volume expansion therapy, intravenous transfusion, plasma substitutes, pregnancy, pregnancy-induced hypertension, pregnancy-induced hypertension, pre-eclampsia and the expansion of treatment for word retrieval. Since 1979 a comprehensive search Pubmed database, Medline database, Ovid databases, Embase database, CJFD, Chinese Biomedical Literature Database, Wanfang database, a master's degree thesis Bo China's outstanding full-text databases, full text of an important conference papers database, an important The full text newspaper database. The scope of manual search for Jilin University Journal of Library and in previous years as the country of origin, including Chinese journal of obstetrics and gynecology, the Chinese Journal of Practical Gynecology and Obstetrics, such as the Journal of the field of obstetrics. Language is restricted to Chinese and English. Manual search to retrieve the current reference and research reports into the original research, evaluating the quality of information extraction and matching. Finally, the research into the meta-analysis. By two researchers independently screened the literature, the article quality assessment (using the Jadad scale score based on) and data extraction. The use of Cochrane Collaboration software provided by Revman4.2 clinical data on the selected data processing and analysis, heterogeneity in selection of appropriate post-test model and, using software-generated maps and funnel plot of forest to the combined statistics testing, sensitivity analysis and analysis of publication bias. Into the literature with the heterogeneity of the time (the results do fit the general description), or the results of sensitivity analysis showed that instability can not draw precise conclusions.Results: A total of five retrieved 297 cases of clinical research, including patient inclusion criteria in line with the literature, 5 are high-quality research literature, are referred to blind, but there is no mention of the specific implementation of the double-blind method; were randomized controlled trials, it was mentioned that the method for randomized sequences of one, did not mention the specific method of random 4; both to visit and losses from the number of cases and the reasons for withdrawal from the description in detail. Extraction of data for Meta analysis and descriptive analysis, the analysis results are as follows: the treatment group compared with the control group, 1) cesarean section rate, RR = 1.08,95% CI [0.96,1.22], P = 0.19, difference no significant results due to the low sensitivity, high stability. Expansion treatment of pre-eclampsia in pregnant women the role of the cesarean section rate with no significant difference between the control group. 2) the rate of premature delivery, RR = 0.91,95% CI [0.26,3.22], P = 0.89> 0.05, the difference was not statistically significant.Expansion between the treatment and control treatment was no significant difference between the study of large and can not draw the right conclusions. 3) perinatal mortality RR = 1.65,95% CI [0.77,3.54], P = O.20> 0.05, due to the low sensitivity of the results, high stability, the expansion of treatment on perinatal mortality in contrast no significant difference between the treatment group. 4) Apgar score <7, the ratio of RR = 1.11,95% CI [0.54,2.28], P = 0.77> 0.05, due to the low sensitivity of the results, high stability, expansion of treatment on the Apgar score less than 7, the rate of birth and no significant difference between the control treatment. 5) the treatment of the rate of expansion will take the application of RR = 1.91,95% CI [0.90,4.05], P = O.09> 0.05, due to the low sensitivity of the results, high stability. Application of expansion on the application of the treatment effects of other drugs with the control treatment group no significant difference.Conclusion: Patients with preeclampsia, the treatment group compared with the control group of patients with pre-eclampsia, capacity expansion and non-treatment group compared to the treatment group: 1) expansion of the treatment of pre-eclampsia in pregnant women on the cesarean section rate, perinatal mortality , Apgar score less than 7, to be the application of the treatment rate of expansion of the role and the control group no significant difference. 2) the treatment of premature expansion rate between the treatment and control was no significant difference between the study of large and can not reach a conclusion. 3) The expansion is still not sure whether the treatment of maternal and fetal outcome of a better effect, so these results should be viewed cautiously. There is a need for high-treatment, randomized controlled trials of samples to be confirmed.
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