Effect Of Xuezhikang On Arterial Elasticity In Patients With Previous Myocardial Infarction

BackgroundWith the improvement of people's living standard and the working stress increasing,the incidence rate of coronary heart disease has been increased year after year.The prevention and treatment of coronary heart disease become a clinical hot spot.Its pathological foundation is coronary artery atherosclerosis.Direct study on coronary artery atherosclerosis need coronary angiography or CT scan.Selective coronary angiography(CAG) remains the gold standard to diagnosis of CHD so far. However,the invasive procedure is costly and dangerously.And CT scan is too expensive.Resent reports suggest that the coronary artery of atherosclerosis has good correlation with peripheral artery.After artery atherosclerosis,the compliance and elasticity of artery decreased.The method of detecting peripheral artery elasticity is simple and cheap. Therefore,researchers predict coronary atherosclerosis by studying peripheral artery elasticity.Xuezhikang(XZK) is one of statins regulating lipid drug invented in china.There are many reports about its regulating lipid in China and abroad,but little has been reported about its effect on peripheral artery elasticity.This paper investigates the effect of XZK on peripheral artery elasticity in patients with previous myocardial infarction,while those of the healthy people and no use XZK were used as controlObjectives1.To research artery elasticity of healthy people and patients with previous myocardial infarction. 2.To investigate peripheral artery elasticity on the patients of long -term using XZK and no using XZK with previous myocardial infarction,then the results were comparing analysed.3.To investigate the relation between FMD and PWV on reflecting peripheral artery elasticity.Methods1.apparatus and drug:XZK were provided by Beidaweixin company,0.3g/cap;GE Vivid 7 Dimension ultrasonic instrument is from American GE company.Colin VP-1000 arteriosclerosis diagnometer is from Japanese COLIN company2.Characters of all subjects:Select the patients were diagnosised as myocardial infarction in 2001～2004 year in Shandong University Qilu Hospital.Among them,38 patients using capsule of XZK 0.6g,twice a day in addition to conventional therapy were the XZK group,39 patients no using capsule of XZK were the no XZK group.The XZK group using XZK at least 1 year(1～6 years,average 2.03 years).The no XZK group never using XZK and the drugs which can affect lipids metabolism.But the drugs which benefit to coronary artery disease,hypertension or others complication can be used.20 healthy people made the control group.Before two days for making the artery elasticity test,the patients were discontinuation any drug.3 groups people were voluntary.3.Ultrasound examination" 3 groups' brachial artery were examined with GE Vivid 7 Dimension high-frequency ultrasonic instrument.In the longitudinal section,intima-media thickness(IMT),systolic inner diameter(Ds),diastolic inner diameter(Dd),absolute inner diameter change(Da),relative inner diameter change(Dr),Mean circumferential wall tension(MCWT),mean blood flow velocity(Vm),Mean shear rate(MSR)and flow-mediated brachial artery vasoactivity(FMD) were examined.4.Pulse wave velocity(PWV) examination:By Colin VP-1000 arteriosclerosis diagnometeris,the brachial-ankle artery PWV(ba PWV) of 3 groups were examined,taken the higher number in the double sides ba PWV.5.Statistic analysis:Measurement data are reported as mean±deciazione standard(SD),enumeration data are reported as cases and percentage.Measurement data and enumeration data were compared with t test and x~2 test by SPSS12.0.For all analysis,a P value less than 0.05 was considered significant.Results1.Characters of all subjects:There are no significant difference in all base line characters(P＞0.05).2.Ultrasound measurement and baPWV:(1) Values of IMT suggest:IMT in healthy group were lower than that in no XZK group(P＜0.01);IMT in healthy group were lower than that in XZK group(P＜0.01);Values of IMT were not significant different between XZK group and no XZK group(P＞0.05).(2) Values of DS suggest:DS in healthy group were higher than that in no XZK group(P＜0.01);DS in healthy group were higher than that in XZK group(P＜0.01);Values of DS were not significant different between XZK group and no XZK group(P＞0.05).(3) Values of Dd suggest:Dd in healthy group were higher than that in no XZK group(P＜0.05);Dd in healthy group were higher than that in XZK group(P＜0.05);Values of Dd were not significant different between XZK group and no XZK group(P＞0.05).(4) Values of Da suggest:Da in healthy group were higher than that in no XZK group(P＜0.01);Da in healthy group were higher than that in XZK group(P＜0.01);Da in XZK group were higher than that in no XZK group(P＜0.01).(5) Values of Dr%suggest:Dr%in healthy group were higher than that in no XZK group(P＜0.01);Dr%in healthy group were higher than that in XZK group(P＜0.01);Dr%in XZK group were higher than that in no XZK group(P＜0.01).(6) Values of MCWT suggest:MCWT in healthy group were lower than that in no XZK group(P＜0.01);MCWT in healthy group were lower than that in XZK group(P＜0.01);MCWT in XZK group were lower than that in no XZK group(P＜0.01).(7) Values of FMD suggest:FMD in healthy group were higher than that in no XZK group(P＜0.01);FMD in healthy group were higher than that in XZK group(P＜0.01);FMD in XZK group were higher than that in no XZK group(P＜0.01).(8) Values of Vm suggest:Vm in healthy group were higher than that in no XZK group(P＜0.01);Vm in healthy group were higher than that in XZK group(P＜0.01);Vm in XZK group were higher than that in no XZK group(P＜0.01).(9) Values of MSR suggest:MSR in healthy group were higher than that in no XZK group(P＜0.01);MSR in healthy group were higher than that in XZK group(P＜0.01);MSR in XZK group were higher than that in no XZK group(P＜0.01).(10) Values of baPWV suggest:baPWV in healthy group were lower than that in no XZK group(P＜0.01);baPWV in healthy group were lower than that in XZK group(P＜0.01);baPWV in XZK group were lower than that in no XZK group(P＜0.01).3.The correlation between baPWV and FMD:baPWV and FMD of healthy group,no XZK group,XZK group were discovered into linear negative correlation,correlation coefficient as follows:healthy group r=-0.571,P＜0.01;XZK group r=-0.68,P＜0.01,no XZK group r=-0.73,P＜0.01.Conclusions1.The artery elasticity of healthy people are better than that of patients with myocardial infarction.2.In the patients with previous myocardial infarction,The artery elasticity in XZK group were better than in no XZK group. 3.FMD and PWV are all good indexes on reflecting peripheral artery elasticity,and they were discovered into linear negative correlation.4.High-frequency ultrasonic instrument and arteriosclerosis diagnometeris are simple and reliable methods on detecting peripheral artery elasticity.5.XZK is an extract from red yeast Chinese rice.It is mixture of multiple statins.XZK not only regulate lipid but also improve artery elasticity.So it is worthy of application and popularization.