Clinical Characteristics And Surgical Treatment Of Invasive Meningiomas

Objective: meningioma is one of the most common tumors in the central nervous system, and some documents reported its incidence was about 20% in all tumors of the intracranial. Most of the meningiomas are benign neoplasms with good prognosis after resection. They generally do not metastasize. But some meningiomas are invasive and have a high rate of local recurrence. There are no definitive criteria to predict local recurrence and invasive feature in meningiomas. In order to supply some evidence for diagnosis and treatment of invasive meningiomas in this study we analyzed the clinical and pathological characteristics of invasive meningiomas.Methods: Sixty-nine cases of invasive meningiomas confirmed by operation or pathology during 2004 to 2006 were analyzed retrospectively.1. We collected the cases of invasive meningiomas who had been diagnosed by operation or pathology in our hospital from December 2004 to June 2006.2. We analyzed the pathological examination, clinic manifestations and preoperative imageology findings of the invasive meningiomas.3. Finally, we evaluated the surgical treatment in invasive meningiomas.Results: There were 48 female cases in those patients, others were males. The most common symptoms were increase in the intracranial pressure, included 32 patients, the other symptoms included the functional disturbance of cranial nerves in 17, epileptic seizure in 11 and other symptoms in 9.Tumor location: In those tumors, 19 were convexity meningiomas, 14 of them at parafalcine and parasagittal sinus, 11 of them at anterior skull base, 7 of them at middle skull base, 16 of them at posterior fossa, 2 of them in intraventricular.Pathological examination: According to WHO classification of tumors of the nervous system in 2000. 56 belonged in grade I, 6 in grade II and 7 in grade III.Surgical treatment: According to Simpson standard of resecting tumor, grade I was reached in 34 cases, grade II reached in 28 and grade III or more in 7.Conclusion: Most of the invasive meningiomas were benign. The preoperative imaging is helpful to making operative plan. Surgery is the basic treatment of invasive meningioma.