| Objective :To study the expression and interaction of cyclin G1,MDM2 and p53 protein in gastric carcinoma, and investigate the possible relationship between them.Methods :the expressions of cyclin G1,MDM2 and p53 protein in 54 cases of gastric carcinoma were detected by immunohistochemical methods.Results:(1)Positive expression rate of Cyclin G1 in gastric carcinoma was 62.96% (),which was significantly higher than that in normal tissues(0%,P<0.05). The expression level of Cyclin G1 was related to histological differentiation, But The expression level of Cyclin G1 was independence to extent of infiltrating , lymphnode metastasis(P<0.05).(2)Positive expression rate of MDM2 in gastric carcinoma was 53.70%(),which was significantly higher than that in normal tissues(15%, P<0.05). The expression level of MDM2 was related to extent of infiltrating , But The expression level of Cyclin G1 was independence to extent of infiltrating , lymphnode metastasis(P<0.05).(3)Positive expression rate of p53 in gastric carcinoma was44.44% (),which was significantly higher than that in normal tissues(0%,P<0.05). The expression level of p53 was independence to histological differentiation,extent of infiltrating , lymphnode metastasis(P<0.05).(4)There is a significant obverse correlation in the expression of MDM2 and p53(P<0.05).Conclusion: The overexpression of Cyclin G1,MDM2 and p53 were found in gastric carcinoma; the expression of Cyclin G1 and MDM2 protein were strongly related to the histological differentiation of gastric carcinoma;But the expression of Cyclin G1,MDM2 and p53 protein were independence to infiltrating , lymphnode metastasis. the expression of MDM2 was positive correlation with p53. CyclinG1,MDM2 and p53 might play an important role in the occurrence and development of gastric carcinoma. |
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