Expression And Clinical Significance Of P130Cas And Paxillin In Human Breast Carcinoma

objective To explore the expression of p130Cas and paxillin in human breast carcinoma and to investigate the relationships of p130Cas and paxillin levels with clinical and pathological characteristics.Materials and methods SP immunohistochemistry staining was applied to detect the expression of p130Cas and paxillin in paraffin section. The 53 cases of primary breast carcinoma,10 cases of breast fibroadenoma and 10 cases of normal breast tissues were collected(These cases all have full clinical and pathology data. All these cases had no other therapy before the operation). The data was checked with Mann-whitney U test, Kruskal-Wallis test and Spearman's rank correlation, respectively. Statistical significance is valuable if P value is less than 0.05. The software SPSS11.5 was applied to analyse the data.Results Breast carcinoma showed higher levels of p130Cas than normal(P <0.001) and fibroadenoma (P <0.001)tissues. The expression of p130Cas in breast carcinoma was positively related with age (rs =0.497,P<0.001), negatively with histological grades (rs= -0.351,P=0.021), but not related with tumor size, lymph node status and pathological stages. p130Cas levels was higher in postmenopausal patients(P=0.007), ER-positive (P=0.001) or PR-positive(P=0.018) tumors.Breast carcinoma tissues showed lower levels of paxillin than normal(P=0.008) and fibroadenoma tissues(P=0.012). The expression of paxillin in breast carcinoma was negatively relateded with pathological stages(rs=-0.387, P=0.004) and histological grades(rs=-0.364,P=0.017), but not related with age, menopausal status, ER, PR status and tumor size. Tumors with more lymphnodes metastasis somewhat showed lower levels of paxillin(P=0.040).Conclusion p130Cas and paxillin have relations with the malignant transformation, invasion and metastasis of breast carcinoma. They can be used as useful factors in the prognosis of breast carcinoma.