Association Of The C161â†'T RFLP In The Peroxisome Proliferator Activated Receptors-gamma And Diet With Dyslipidemia And The Metabolic Syndrome

Objective To study the genotype frequencies of peroxisome proliferator activated-receptors- gamma C161→T gene,and to analyze the possible association of it and diet with dyslipidemia and the metabolic syndrome.And to provide basic information of the individual prevention and control to dyslipidemia and the metabolic syndrome.Methods The PCR-PFLP method was used to detect the polymorphism of PPARγ, C161→T gene of the adults in Shanghai.Their physical examinations,dietary investigation, the serum biochemistry were analyzed.The possible association of polymorphism of PPARγC161→T gene and diet with dyslipidemia and the metabolic syndrome was analyzed.Results①The genotype frequencies of PPARγC161→T CC,CT and TT were 35.1 %,47.0%and 17.9%respectively,which were in agreement with Hardy-Weinberg equilibrium.②After adjusting age,gender and body mass index,the levels of TG were significantly different among three genotypes groups.Subjects of the CT genotype had the highest TG level.The levels of body mass index,waist width and hip width were significantly different among three genotypes groups.Subjects of the CT genotype had the highest level.③After adjusting age and gender,the intakes of protein were significantly different among three genotype groups.④There was significant difference in the negative correlation between the intake of energy,protein and carbohydrate and serum TG level in the dyslipidemia group.⑤There was significant difference in the negative correlation between the intake of protein and serum TG level in the metabolic syndrome group. Conclusion PPARγC161→T gene polymorphism influenced serum TG levels and BMI levels, while associated with proteins intakes.But there was no speciality of PPARγC161→T gene polymorphism in dyslipidemia and the metabolic syndrome.It might contribute to the heterogeneity in TG response to dietiary intervention.