The Analysis Of Serum Adiponectin In Primary Nephrotic Syndrome

OBJECTIVE: To investigate serum adiponectin and serum creatinine, hepatic function, blood lipid, the fasting blood glucos, 24-hour proteinuria in patients with primary nephrotic syndrome, and to analyze the relationship between serum adiponectin and these factors.METHODS: By using enzyme-linked immunoadsordent assay (ELISA) methods, the fasting levels of serum adiponectin were measured in 25 patients with primary nephrotic syndrome, 25 patients with primary chronic glomerulonephritis but without nephrotic syndrome and 25 healthy subjects. Serum creatinine, hepatic function, blood lipids, the fasting blood glucose, 24-hour proteinuria, blood pressure and BMI were reassayed and compared simultaneously. Patients with primary nephrotic syndrome were on treatment with prednisone and some other medicines that can normalize blood lipids and blood pressure level. After 8 weeks' treatment, serum adiponectin , serum creatinine, hepatic function, blood lipids, the fasting blood glucose, 24-hour proteinuria, blood pressure and BMI were remeasured and compared.RESULTS:①The levels of serum adiponectin in patients with primary nephrotic syndrome (28.47±10.15 vs 7.13±2.29 mg/L) and in patients with primary chronic glomerulonephritis but without nephrotic syndrome (15.43±5.38 vs 7.13±2.29 mg/L) were significantly higher than those in healthy subjects, and the serum adiponectin concentration in patients with primary chronic glomerulonephritis was significantly lower than those in patients with primary nephrotic syndrome; however, the level of serum adiponectin remarkablely decreased after treatment (28.47±10.15 vs 12.97±6.56 mg/L) in the NS group.②Univariable analysis showed that serum adiponectin negatively associate with albumin and total protein (r = -0.61 vs r = -0.63) and positively associate with proteinuria and lipoprotein (a) (r =0.844 vs r =0.558) in patients with primary nephrotic syndrome.③Multiple regression analysis showed proteinuria to be the highest influence.CONCLUSION: The level of serum adiponectin in patients with primary nephrotic syndrome was significantly higher than primary chronic glomerulonephritis but without nephrotic syndrome and healthy subjects, and was positively related to proteinuria and lipoprotein (a) , and was negatively associated with albumin and total protein. The level of serum adiponectin of NS group was obviously decreased after therapy. Results suggest that adiponectin may be involved in lipid metabolism disorder nephrotic syndrome regulation, but the specific mechanism is not yet clear.