Synthesis And Structures Of Organoselenium Compounds

Selenium is one of the most important elements,the reactions about selenium have been investigated widely and applied in many fields.The bio-activities of organoseleniums attracted much attention.Selenides,deselenides and heterocyclic compounds containing selenium are synthesized and studied thoroughly.It is a hot topic for the coming days to synthesize some new compounds containing element selenium.And now,the most successful example is ebselen.In this paper,according the planning of the work,some new compounds containing selenium were synthesized and structurally characterized.The main task of our investigation is to design and synthesize some new organoselenium compounds which would exhibit higher bio-activities.The details of the dissertation are listed as follows.Chapter 1.The background of the research work was introduced.It is divided into three sections:(1) chemistry of selenium,the applications and research developments of selenium in inorganic,organic and biochemistry;(2) organoselenium compounds and their bio-activities;(3) the prospective for the development of organoselenium chemistry.Chapter 2 Some new ebselen analogues 2a-2e were synthesized and characterized by X-Ray single crystal diffraction,NMR technology and elemental analysis.Chapter 3 The compounds 3a-3e were synthesized from 2-chloropyridine-3-carboxyl-ic acid as starting material,the non-bonded interactions between Se atom and neighbored O or N atoms in the crystals are discussed.Chapter 4 The compounds similar to 2-Chloro-nicotinamide reacted with Na₂Se₂ directly,The new2,2'-diselenobisnicotinamide compounds 5a-Se were synthesized. The X-ray data for compounds 5a,5b,5d and 5e are provided.Chapter 5 Synthesis and structural characteristics of the novel compounds 6a,6b, 7a and 7b.In the summaries for the paper,the method of detecting the bio-activities of all the compounds synthesized are investigated.