Correlation Between Mta-1 Expression And VEGF Expression In Bladder Transitional Cell Carcinoma

Bladder transitional cell carcinoma (BTCC) is the most common malignant tumour in urinary system. Postoperative recidivation and metastasis are common reasons lead to failure of treatment. The occurrence and growth of tumour correlate with the activation of oncogene and the mutation and/or absence of anti-oncogene. After Mta-1 was found in recently,it was paid extensive attention to in cancer research area. New vessels is the base of the growth and metastasis of tumour. VEGF protein is considered the most effective and specified regulator of angiogenesis. It correlate with many tumours including BTCC. Objective To explore the effect of Mta-1 and VEGF in the occurrence and development of BTCC and their clinical value. Methods In 40 cases of BTCC and 10 cases of normal tissue bladder, The correlation of Mta-1 and VEGF expression examined with immunohistochemical analysis and their correlation with the invasion,metastasis,angiogenesis and recurrence of BTCCs was analyzed.The correlation of Mta-1 expression with VEGF was analyzed. Results The positive rates of Mta-1 expression were 70.0%(28/40) in BTCCs and 0.0% in normal bladder mucosa tissues(P<0.05).The expression level of Mta-l increased with the higher clinical stages and pathologic grades of BTCCs;it was higher in recurrence group than in non-recurrence group,and higher in metastasis group than in non-metastasis group (P<0.05).The expression level of VEGF increased with the higher clinical stages of BTCCs. The positive rate of VEGF expression was significantly higher in BTCCs than that in normal bladder mucosa tissues(P<0.05).Positive correlation was found between VEGF and Mta-1 expression(rs= 0.762, P<0.05). Conclusions Mta-1 and VEGF correlates closely with tumor recurrence and metastasis;Mta-1 was positively correlated with Mta-1 in BTCCs.