| Objective: Burns are difficult to treat, wounds with complex local and systemic pathology and high mortality, that often heal slowly with scars and contractures. Glycosaminoglycans (GAGs) have been used in parenteral and topical application studies. These studies have uncovered anticoagulative, antiinflammatory and neoangiogenic properties, which may stimulate tissue repair and reepithe-Halizing effects. Heparin, the most sulfated and acidic GAG, has been used parenterally, topically, by inhalation, in pellet, and in bioengineered membranes. Heparin relieved pain, inhibited clotting and inflammation, restored blood flow, and enhanced healing. Heparin reduced needs for pain medicine, topical antibiotics,resuscitation fluids, blood, water baths, debridement, surgery and grafts. Cost of treatments were reduced. Although not as yetfully substantiated, topical heparin therapy of burns may be a useful addition to the range of available treatments for burnwounds. This study was to investigate the effects of heparin on deep partial thickness burn wound.Method: Thirty cases inflicted with 3%-50% TBSA deep partial thickness burn wound, after fresh wound was debrided, the treating area was handled with heparin and Sulfadiazine silver cream, while the control area was treated with Sulfadiazine silver cream, until the wound healing. Reliving pain and the wound healing time were observed simultaneously.Result: Pains were relieved after the wound handled with heparin; the wound healing time was much shorter in Heparin area than in SD-Ag area(p<0.05). Conclusion: It is suggested that topical application of heparin to deep partial thickness burn wound may alleviate the progressive tissue damage, relive pain during early stage and promote wound healing. |
