Correlation Between Recurrence And Expression Of VEGF,MVD,16-slice Helical Computed Tomography Dynamic Enhancement In Meningiomas

Objective To investigate the relationship between recurrence and expressioon of VEGF,MVD and 16-slice helical computed tomography dynamic enhancement in meningiomas, and evaluate its clinical usefulness.Methods MVD,the expression of VEGF were examined by immunohistochemical method, the finding of CT dynamic enhancement were reviewed , and then the relationship between recurrence and them were analysised in 33 recurrence and 26 primary meningiomas.Results①The general average of MVD in the primary and recurrent meningiomas was respectively 34.2923±17.2422,71.41±39.475, it was significantly higher in the recurrent group( P=0.000 < 0.05); The general average of MVD was respectively 54.7304±25.3080,109.78±39.642 in the recurrent meningiomas of gradeⅠand gradeⅡ,Ⅲ,it was significantly higher in the recurrent meningiomas of gradeⅡ,Ⅲ( P=0.000 < 0.05).②The expression of VEGF was respectively 39.13%(9/23),11.54%(3/26)in the recurrent meningiomas of gradeⅠand primary meningiomas,the former was higher than the latter(P=0.044<0.05).③The general average of MVD was 37.9263±15.2300 in 38 meningiomas which was negative expression of VEGF , while it was 86.0286±28.7464 in 21 meningiomas which was positive expression of VEGF. Expression of VEGF was positively correlated with general average of MVD (r=0.7888,P<0.001).④The slope rate of time density curves(SR-DTC) in 16-slice CT dynamic enhancement of meningiomas was positively correlated with general average of MVD(r=0.33,P<0.01).Conclusion: Expression of VEGF,MVD and 16-slice CT dynamic enhancement in meningiomas were examined combined,and they may be an important prediction marker for detecting the clinical pathological characteristics of meningiomas.