Distribution And Drug Resistance Of Gram-Negative Bacteria From Respiratory Tract Infection

Objective: To investigate the distribution and drug resistance of Gram-negative bacteria of respiratory tract infections in our hospital, guide clinical use of antibiotic drugs.Methods: This is a retrospective study of last three years. We collected and analyzed materials of sputum from 2007 January to 2007 December in our hospital, contained identification of bacteria and susceptibility test. The identification of strains were detected by VITEK-2 system from France, and drug resistance by method of Kirby-bauer. The result was assessed by CLSI.Results: A total of 2196 strains in 2007 were detected,of which,Gram-positive bacteria were 275 strains(12.52%) and Gram-negative bacteria were 1921 strains(87.48%).The major Gram-positive bacteria were Staphylococcus aureus,93.09% of Gram-positive bacteria. The major Gram-negative bacteria were Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, Stenotrophomonas maltophilia Aeromonas and Escherichia coli., as 39.41%, 18.90%, 12.86%, 9.47%, 6.35% of Gram-negative bacteria. The result of drug resistance indicated that Pseudomonas aeruginosa, Enterobacter and Serratia were all highly multi-resistant. Compared with 2005 and 2006, there's no difference in bacteria spectrum.Conclusion: Recent 3 years, the major pathogenic germs of respiratory tract infection diversify little, are gram negative bacteria as before, which are multi-resistant and gradually increasing.