Expression Of Bone Morphogenetic Protein Receptor Type IA In Retina Of Early Type 2 Diabetic Rats

Objective To investigate the role played by the bone morphogenetic protein receptor type IA (BMPR-IA) in pathogenesis of early diabetic retinopathy by observing the expression patterns of BMPR-IA in retina of early experimental type2 diabetic rats.Method Fifty-four male Wistar rats were divided into 2 groups randomly: control group (n=24) and diabetes group (n=30). Both groups were divided into 4, 8 and 12 weeks groups. Diabetes groups were used to establish the type 2 diabetic models by intraperitoneal injection with small dose streptozotocin (STZ) after been fed with special food which contains high sugar and fat for 5 weeks. All of the rats were executed at the right point. The expression of BMPR-IA protein was detected by immunohistochemistry method and computer image analysis. Results Strong positive expression of BMPR-IA in retina was detected in normal control groups. In the diabetes groups of 8 and 12 weeks, the expression of BMPR-IA decreased obviously comparing with which in the control groups (P<0.05).Conclusions Not only BMPR-IA is important for maintaining normal physiological function of the retina but also may regulate the development of early diabetic retinopathy negatively.