| Psoriasis is a common, chronic, inflammatory and benign hyper- proliferation disease. It is stubborn ,recurrent and refractoriness desease. So far there are no adeal therapy for psoriasis.Recently, retinoids has become one of the effective medicine for treatment of psoriasis. Huangqi injection includes the major effective components of Huangqi herb. Modern pharmacological studies have indicated its immunoenhencement and immunoregulatory effects. Previous observations have also shown its clinical effects on psoriasis, but the mechanism has not been known clearly.Objective: In this study, the therapeutic effects of arotinoid ethylester capsules were compared with acitretin capsules. The therapeutic effects of Huangqi injection were also observed when combined with arotinoid ethylester capsules and acitretin capsules.Methods: One hundred and seven psoriatic patients who were diagnosed clinically or by pathologic method were divided into two groups according to the admission time. The 41 cases of the first group were treated with Arotinoid ethylester capsules. The 66 cases of the second group were treated with acitretin capsules. At the same time, some of the patients in every group were treated with Huang-qi injection. Therapeutic effects were determined with PASI scores and comparing the effects. The deference of effective rate between the patients treated with Huang-qi injection and the patients without the injection was statistically analyzed.Results: The effective rate of the two groups were 82.9% and 78.8% respectively. And the patients with Huang-qi injection got better therapeutic effects. But there was not obvious difference between arotinoid ethylester capsules and acitretin capsules. Conclution: Both arotinoid ethylester capsule and acitretin capsule are effective on treatment of psoriasis. No obvious deference in curative was found between Arotinoid ethylester and acitretin. Huangqi can increase efficiency on psoriasis while combined with the drugs above.
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