| Objective Compared the characteristics of age of onset,predilection sexuality,clinical manifestation,laboratory examination and immunology index in systemic lupus erythematosus(SLE)of children and adults,searched for their difference and similarness,explored the development rules of children SLE. Provided valuable experience to make earlier diagnosis and therapy,raised curative effect,lengthen the life span of patients and raised their quality of life.Method Retrospectively analysed the age,sex,initial symptoms, regular laboratory examination and immunologe feature of 50 children in GXMU dermatology and pediatrics departments during 2000 Jan and 2005 Dec, compared with 357 adults SLE in the same time,and then drew a conclusion by statistical analysis.Result①The ration of male and female in children group was 1:5.25,children older than 10 years account for 94%;the ration of male and female of adults group was 1:6.44.there was no significant difference of composition of sexuality between the two groups(P＞0.05),the females were in higher incidence rate.②The most common initial sympton in children group was facial erythema,there was significant differnce between the two groups(P＜0.05),the children SLE in higher incidence rate.③There was significant difference of the incident rate of arthralgia in the two groups in noninitial sympton(include dianogisis standard),the children group was lower. ④In the blood RT:the significance of the level of erythrocytopenia, leukocyte and lymphocytopenia were different(p＜0.05),the children group decrease extent were lower than adults.⑤There was no difference of incidence rate of kidney damage in two groups(P＞0.05).⑥No obvious difference in the incidence rate and level of the ESR in different groups (P＞0.05).⑦There is no obvious difference in the incidence rate and level of the ANA,ds-DNA,C3,C4,ENA among the two groups(P＞0.05).Conclusion①Children SLE most happened after 10 years old,the incident rate of female children was higher;the proportion of sexuality of two groups was samely.②The most common initial symptom of children SLE was facial erythema,which was easy to misdiagnosis,we should be caution in clinical.③We should pay attention to the decrease of the RBC and WBC in pristine children SLE,which were slighter than adults,we should be diagnose combine together the clinical symptom and bodysign.④There were higher similarity of the two groups in predilection sexuality,clinical manifestation (exclude facial erythema and arthralgia),intemal organs' damage,common practice laboratory examination,immunology changes,so the diagnose and cure of children SLE can reference to adults SLE.
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