The Relationship Between Type 2 Diabetic Vascular Complications And Serum Ferritin

Objective and backgroundDiabetic vascular complications are the most important reasons which could cause patients with type 2 diabetes fatality. Emerging scientific investigations have intention to search for the reason and mechanism. Serum ferritin(SF) are the protein which have most redundant iron in our body, reflecting the total amount iron store, and effective indicator of iron deficiency or overload. Recently, lots of scientific investigations abroad have disclosed unsuspected influences between iron metabolism and type 2 diabetes. Increased iron stores have been found to predict the development of type 2 diabetes while iron depletion was protective, iron-induced damage might also modulate the development of chronic diabetes complications. Here, we observe the relationship between type 2 diabetic vascular complications,SF levels and other correlated metabolism indicators, approaching the relationship between type 2 diabetic vascular complications and serum ferritin , in order to provide theory evidence of diabetic vascular complications prevention and cure for clinical use. Objects and methodsA total of 100 type 2 diabetes patients and 100 healthy people were entered into our study. All subjects were evaluated SF,fasting blood glucose(FBG),insulin(FINS),Cpeptide,glycosylated hemoglobin (HbAlc),triglyceride (TG),total cholesterol (TC),low-density lipoprotein (LDL),high-density lipoprotein cholesterol (HDL),24 hours urinary albumin excretion rate (UAER) and arteria carotis ultrasonic inspection. The age and sex were matched each other in patients and controls. We analyzed the relationship among them. All data were used SPSS13.0 software to progress statistical analysis. There was significantly difference if p<0.05.Results1. SF levels in type 2 diabetic patients were significantly higher than in healthy controls (p<0.01).2. SF levels of poorly controlled patients were significantly higher than those of moderately controlled patients (p<0.05) and healthy controls(p <0.01); Moderately controlled patients were not significantly higher than healthy controls.3. SF levels of clinica albuminuria group were significantly higher than those of microalbuminuria (p<0.05) and normal albuminuria (p<0.05); microalbuminuria group were significantly higher than those of normal albuminuria (p<0.05); all albuminuria groups were significantly higher than healthy controls (p<0.01).4. SF levels of type 2 diabetic patients with arteria carotis defect were significantly higher than those of patients without arteria carotis defect (p<0.05). 5. Pearson correlation analysis showed that SF levels was significantly positively correlated with FINS,UAER/24h,HbA1c,HOMA-IR (p<0.01); Multiple linear regression showed SF was the independent variance of FINS,UAER/24h and HOMA-IR.ConclusionElevated SF levels may be an effective indicator of development in type 2 diabetes and diabetic vascular complications. People with serum high-ferritin could take notice of insulin resistance,carbohydrate tolerance dysfunction or diabetes. The clarification of the mechanisms that regulate this interaction are proposed to contribute to improve the management of diabetes and to anticipate its possible complications. Iron store depletion seem beneficial in optimizing diabetic metabolic control.