The Clinical Study On Detection Of Brain Iron Content In Epileptic Patients Through SWI And The Changes Of Serum Iron And Serum Ferritin

ObjectiveTo determine the serum iron(SI)by atomic absorption spectrophotometer,the serum ferritin(SF)by radiolabeled enzyme linked immunosorbent assay(ELISA)and brain iron levels by magnetic susceptibility weighted imaging(SWI),and investigate the contents of iron and ferritin in the peripheral blood and the content of brain iron in epilepsy and provide new ideas for monitoring and treatment the diagnosis of epilepsy.MethodsThirty-five patients were recruited from our hospital in neurology outpatient department and hospitalization diagnosed epilepsy from May 2015 to December 2016 as the epilepsy group.Patients(19 men,16 women)aged between 18 to 81 years old(average 56.1±11.6),who had a mean disease duration of 1-18 years(average8.2±4.5).Twenty-four healthy persons(11 men,13 women)as the control group,whose age matched with the study group,aged between 20 to 79 years old(the average50.4±9.7).Serum iron and serum ferritin were determine.MRI routine and SWI sequence scanning were examined.The phase value of the bilateral frontal white matter(FWM),caudate nucleus(CN),putamen(PUT),globus pallidus(GP),thalamus(THA),red nucleus(RN),substantia nigra(SN)and temporal lobe(TL)were evaluated in the corrected phase image,statistical analysis of the numerical.Results1.There is no significant difference between the epilepsy group and the control group in serum iron and serum ferritin levels,p>0.05.2.The phase values of regions of interest(ROI)in epilepsy group and in control group is no statistically significant,p>0.05;3.In the epilepsy group and the control group,there is no significant difference of the phase values in the ROI about different gender subjects,p>0.05;4.The phase values in frontal white matter,caudate nucleus,putamen,red nucleus,substantia nigra and temporal lobe in different age groups was statistically significant,p<0.05.They are negatively correlated with age.With the increasing of age,the phase values reduce and the iron content decreases in brain.The phase values in thalamus and globus pallidus in the same age group have no statistical significance and correlation with age,p>0.05.There is no significant difference of phase values in the ROI in the epilepsy group of different age groups,and there is no correlation with age.5.The phase values in epilepsy group are higher than those in the control group in the caudate nucleus,putamen,globus pallidus,red nucleus and substantia nigra,and there are significant difference(p<0.05),and the phase values in red nucleus and substantia nigra have extremely significant differences(p<0.001).While the phase values in epilepsy group are lower than those in the control group in frontal white matter and temporal lobe,and the differences of phase values in frontal white matter are statistically significant(p<0.05),but the differences of phase values in temporal lobe have no statistically significant(p>0.05).Comparison with the control group,the iron content in caudate nucleus,putamen,globus pallidus,red nucleus and substantia nigra are significantly lower than that in the control group,and the iron content in frontal white matter decreases.6.There was no significant difference on ROI between the two groups in the different stages of epilepsy in the epilepsy group(p>0.05).7.The diferences of phase values in frontal white matter,red nucleus,substantia nigra and temporal lobe are tatistically significant and have significant correlation(correlation coefficient 0.425,0.316,0.541,0.335,p<0.05).Conclusion The content of iron in normal human brain is not unilateral,and it has no relation with sex.With the increasing of age,some of the nuclei in the brain appear physiological iron deposition.The contents of serum iron and serum ferritin are normal in epilepsy,and the content of brain iron in epileptic patients increases in the cortex and decrease in the subcortex,and the brain iron is redistribution,and the changes of the content of brain iron is correlated with seizure type.Susceptibility weighted imaging is sensitive to iron deposition,which can be used to quantitatively determine the change of brain iron content.It provides a new method for the diagnosis and monitoring of epilepsy.