Pharmaceutical Research Of Zixiang Yimu Capsule

ZiXiang YiMu CaPsule is consisted with ethno-medicine ,suchas Sophora flavesens Ait,Phellodendron amurense Rupr , Polygonum perfoliatum L. and so on.ZiXiang YiMu CaPsule is beneficial for treating infla mmatory of gynecology.1 Study on the preparationAccording properties of the herbs of the prescription and the need in the clinie, the ZiXiang YiMu capsules are selected as the dosage form of the drug. The optimum extraction condition was studied by ort hogonal test regarding matrine and oxymatrine content of the main herb drug Radix Sophorae Flavescentis by utilize of HPLC. And the berberine content of Cortex Phellodendri. And extraction rate of the ZiXiang YiMu capsule as the indicating standards. And getting the conelusion that the optimum extraction process was reliable : used the crude cutting drug size, boiliing 3 times, 1.5 h each time,the amount of water was 12 times of amount of the crude drug amount. The optimum extraetion method is selected by single factor test regarding matrine and oxymatrine content of t he main herb drug Radix Sop horae Flavescentis by utilize of HPLC. And the berberine content of Cortex Phellodendri. And extraction rate of the ZiXiang YiMu capsule as the indicating standards. Getting the conelusion that the optimum extraction process: put the concentrated solution(about 0.2 g/ mL) in the temperature of 10-30℃,adding Ethanol absolute solution whic h is 70 % of the amount of the concentrated solution,and positioned 24 h in 5-10℃.The observation of the effect for the property of the extracting-power with different auxiliary component is done by contrast experiment,the study of moulding preparation shows that when the proportion of extracting-power and microcrystal cellulose and starch is 5:0.5:0.5 the moistureabsorption of the extracting-power can be lowered and has a good fluidity mixing the extracting-power and the auxiliary component,the critical contrasting humidity is about 62.5 % divide one capsule equally. The package was 0.24 gram for each capsule.2 Study on quality standardSophora flavesens Ait, P hellodendron amurense Rupr , Poly-gonum perfoliatum L. were indentified by TLC. The sep-aration of the stains is apparent, the negative constrastnot disturbed. Using HPLC to determine matrine, oxymatrine,and berberine eontent, according to the methological study, this method is reliable and can be used to measure the con-tent of preparations.