Research On 2D Ventricular Model-Based Electrocardiogram Simulation

For a long time, heart disease diagnosis, treatment and prevention dependent mainly on body surface electrocardiograms (ECGs) or vectorcardiograms (VCGs). Since the relationship between the body surface ECGs and the cardiac work state can not be understood completely, there is much limitation when the ECG or VCG is used for clinic diagnosis. In order to know the precise relationship between these, animal or human experiments can be made. However, these experimental methods are time consuming, costly, dangerous, and difficult to get satisfactory results. Applying and developing computer model of heart electrical activity can solve this problem perfectly. It can not only look for the relationship between the heart condition and surface potential, but also can be used to estimate the epicardial potential distributions and the law of cardiac electrical activity when we get the measured data of body surface ECGs, which could be a big help for doctors making more precise diagnosis.Simulation models of heart electrical activity in both organization level and organ-class level were developed in this paper. Firstly, an idealized model of tissue patch in ventricular wall was established and electric conduction process in tissue patch and pseudo-ECG in periphery of tissue were simulated.Secondly, the tissue patch model was used to simulate the ECG waveforms under pathological conditions, mainly for Brugada syndrome and LQT syndrome. On one hand, these simulations illustrate the relationship between ion channel and ECG waveforms; on the other hand, the tissue patch model is assessed from a perspective of pathological way.Finally, a two-dimensional anatomical model of ventricle was developed to simulate the excitation sequence map and the six chest-lead electrocardiograms of ventricle, which makes a transition from organization level to organ-class level and lays a good foundation for establishing three-dimensional model of the whole heart in future.