The Study Of Dendritic Cell Phenotypic Antigen In Cervical Carcinoma

Objective Dendritic cells express many cell phenotypic antigens,they have different special function in the process of antigen present. The purpose of this study was to determine some DC phenotypic antigen in the tumor immunoreaction.Methods Envision was performed using antibodies against the cell surface markers S-100,CD1a and CD83. 45 cases of cervix carcinoma were included in this study.Results The number of S-100+DCs in poor differentiation cases were few. CD83+DCs were few in the case of poor differentiation,lymph node metastasis,recurrence difference between the number of CD83+DCs and CD1a+DCs. CD83+DCs located at the peritumor area mainly.Conclusions The expression of dendritic cells phenotypic antigens were significant difference in different areas in lymph nodes and many play different role in tumor immunity against cervix carcinoma.Dendritic cells phenotypic antigens were the important index to predict the prognosis of the patients with cervix carcinoma.