The Induction Of Specific Antitumor Immunity Activated By Dendritic Cells Loaded With Different Types Of Antigen Against Cervical Cancer

Cervical cancer is the most common gynecologic malignant tumor in developing countries. A lot of evidences exist to show that both the incidence and mortality rate can be reduced by the use of cervical screening programs.However, cervical cancer remains still the second leading cause of cancer death among women in developing countries. The major causative agent of this disease is considered to be human papillomavirus (HPV) infection. Over the past 15 years, epidemiological data have identified the fact that there is a consistently strong relationship between HPV infection and cervical neoplasia, and HPV DNA has been detected in more than 99.7% of cervical cancer and its precursors. The use of HPV typing shows that HPV 16 is a predominant etiological agent and presents in approximately 50% of all the disease . Therefore, HPV 16 has become a target for the development of HPV vaccine.In addition to infectious factor ,immunosuppression is another risk factor for the development of cervical cancer. In studies of women with immunosuppression such as renal transplants and HIV-infected,significantly higher incidence of cervical cancer was found.Recently ,as the fourth tumor therapeutic pattern,biotherapy including immunotherapy and gene therapy has concentrated more and more attention,also it has become the important assistant approach to the therapy of cervical carcinoma.T lymphocyte-dependent immunity is the major cellular immunity to tumors...