The Study On Character And Variational Tendency Of Birth Defect In Fujian, China

ObjectiveTo analyze the variational tendency of birth defect from 1986 to 2006 in Fujian,China. Furthermore to explore the possible risks, which were evaluated in company with its distribution characteristic subsequently.And provide some scientific guidelines for the prevention and intervention of birth defect.MethodsData from 1986 to 2006 were collected via Fujian Birth Defect (BD) Monitoring Network―a hospital that based on planning congenital anomalies registry system as a whole. During that period all lives or stillbirth with 28 weeks or more of gestation were assessed within 7 days after delivery. The overall rates of general incidence and typical incidence, ranking and long-term trend were evaluated. By using Chi-square test,t-test, biological regression and time series analysis, ,odds ratio and 95% confidence interval, A 1:1 matched case control study was designed to be described and evaluated from October 1,1986 to August 3,1992. By means of simple and multivariable conditional logistic regression, the odds ratio and 95% confidence interval were computed. Moreover, the interaction for the important risk factors was analyzed.ResultsThe overall prevalence rates of birth defect were rising yearly( Linear-by-Linear Associationχ2=5.708,P<0.05) The incidence of birth defect is varied in different seasons and especially higher in summer.There were different BD orders in rural and urban. The BD risk of anencephalus, cleft spine, deformity of external-ear, limbs decurtation, congenital diaphragmatic, hernia, hydrocephaly ,cleft and varus were higher in rural than that in urban (P<0.05,OR>1), which holds the higher risk of gullet-clausura, bladder exstrophy, congenital cardiopathy .The results of multivariable non-conditional logistic regression showed that birth defect was mostly caused by the exposure to ray,exposure to chemicals,exposure to pesticide,exposure to antibiotic,exposure to smoking,exposure to Chinese herbal medicine,by being abnormal in the duration of pregnancy, which including having a fever or any diseases, drinking, smoking, in touch with chemicals, antibiotic, by women's age that beyond 35, and also by their low education background. the season of androlepsis,Respectively OR and 95% confidential interzone (CI) were:22.9,(95% CI=2.798～186.676);16.5,(95% CI=8.051～34.004); 15.0,(95% CI=4.661～48.5120);12.7,(95% CI=3.330～48.086);11.4, (95% CI=2.187～2.905);8.220,(95% CI=5.783～11.665); 4.830,(95% CI=3.196～7.299);4.017,(95% CI=2.877～5.610); 3.390,(95% CI=1.149～10.001);3.724,(95% CI=2.777～4.995); 2.607,(95% CI=1.779～3.822); 1.670,(95% CI=1.147～2.432).As a result, interactions were found between smoking and drinking. (OR=34.560,95% CI=25.528～46.789),ConclusionFrom 1986 to 2006, the prevalence rate of congenital anomalies is increasing gradually in Fujian ,China. The main risk factors of birth defect are the season of androlepsis, abnormal in the duration of pregnancy, high women's age aged 35 or over, and women with low education level.In order to decrease the rate of birth defect, serveral efficient and feasible ways can be fetched out as follows: raising resistance of illness, abstinence, away from poisonous chemicals, noise and ray , adjusting the occupation before pregnancy, accepting education, enlarging health education, making the knowledge of birth defect wild-spread and executing the three-stage protection against birth defect.