| Objective: The topic will be on 100 cases of refractory non-small cell lung cancer (NSCLC) on the 1st of lung cancer patients using the treatment (treatment group 52 cases) and a single chemotherapy treatment (control group of 48 cases), for the recent efficacy, quality of life, toxicity reaction, immune function, tumor markers observed in the control study to further clarify on the 1st of lung cancer, non-small cell lung cancer, and its treatment of non-small cell lung cancer may be the mechanism for medicine in the treatment of non-small cell lung cancer provide relevant theory.Methods: Will be consistent with the standards included in advanced non-small cell lung cancer cases 100 cases, according to Chinese medicine into treatment in the treatment group and the control group were chemotherapy, prospective study. TCM treatment group to be on the 1st of oral medicine in the Treatment of Lung Cancer, and with the addition and subtraction of, the one, a two or more points clothes, a month for a course, the period of observation for three courses; chemotherapy regimen used Recommended for advanced NSCLC programme GP or conventional TP programme to three weeks for a course of treatment, so a total of three treatment observation period before the start of chemotherapy to only two weeks after the end of chemotherapy. Then the two groups were observed in patients with clinical symptoms, quality of life, weight changes, timely observation tumor size, the T-lymphocyte subsets, tumor marker cytokeratin 19 fragments (CYFRA21-1), and other indicators of change, as well as adverse drug reactions , and so on, and compared.Result:1.changes in the tumor: the group on the 1st of lung cancer after treatment efficiency of 9.62%, stable rate of 76.92 percent, compared with the chemotherapy group and efficient without significant difference (P> 0.05), but steady rate significantly different (P <0.01);2. clinical symptom score: two points clinical symptoms after treatment than before treatment reduced, but on the 1st of lung cancer, more significantly decreased after treatment, after treatment with chemotherapy group compared There was a significant difference (P <0.01);3. the quality of life assessment: two groups of patients before treatment KPS score, P> 0.05, comparable. After the treatment, lung cancer increase on the 1st group of 27 cases, 17 cases of stable, lower eight cases, the rate of increase stability 84.62%; chemotherapy group an increase of 11 cases, 10 cases of stable, lower 27 cases, the increase rate of 43.75 percent and stability, the two groups Comparison There was a significant difference (P <0.01);4. weight changes: the lung cancer group on the 1st to maintain and increase body weight, increase stability rate of 76.92%, 39.58% better than chemotherapy group (P <0.05);5. toxicity: lung cancer group on the 1st, less toxic reaction, only one case of aâ… of renal damage, chemotherapy and bone marrow suppression have a certain degree of hepatic and renal dysfunction;6. and immune indicators CYFRA21-1 levels: on the 1st of lung cancer after treatment group, the total number of T cells, helper T cells and NK cells was higher than that in the chemotherapy group, and inhibition of T cell CYFRA21-1 level and below the average water chemotherapy group.Conclusions:1. On the 1st of lung cancer can improve clinical symptoms, particularly in the cough, lack of appetite, shortness of breath, fatigue, fever and other symptoms ease, with good effect;2. On the 1st of lung cancer can keep the tumor stability, inhibit the development of lung cancer, and improving the quality of life, increasing body weight; 3. on the 1st of lung cancer can increase T cells, the number of NK cells or enhance its functions and enhancing the cellular immune function, a certain synergies;4. On the 1st of lung cancer can be reduced to the content of CYFR21-1, adjusting the level of tumor markers and expression, the body of the material to improve metabolism and restore yin and yang in balance. |
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