The Change And Significance Of ANP And ET-1 In Patients With Fetal Growth Restriction

Objectives:To investigate the relationship about atrial natriuretic peptide(ANP)and endothelin-1(ET-1)with fetal growth restriction,we detected the concentration of the two hormones(ANP and ET-1)in maternal elbow vein blood and umbilical vein blood from patients with fetal growth restriction.Methods:Twenty-three normal late pregnant women and their infants(control group),twenty- three mothers of FGR and their infants were studied(FGR group).The concentration of ANP and ET-1 in maternal elbow vein blood and umbilical vein blood were determined by Radioimmunoassay(RIA).These experimental datas was analized by the software SPSS 13.0.Results:(1)The concentration of ANP in elbow vein blood of control group was (0.12±0.04)ng/ml.The concentration of ANP in elbow vein blood of FGR group was (0.08±0.04)ng/ml,which is lower than the the concentration of controls.The difference was statistically significant(P＜0.05).(2)The concentration of ANP in umbilical vein blood of controls was(0.15±0.04)ng/ml.The concentration of ANP in umbilical vein blood of FGR group was(0.12±0.05)ng/ml,which is lower than the concentration of congtrols.The difference was statistically significant(P＜0.05).(3) The concentration of ET-1 in elbow vein blood of controls was(62.22±11.47) pg/ml,the concentration of ET-1 in elbow vein blood of FGR group was(65.87±8.74) pg/ml.There was no statistical difference between the data of two groups(P＞0.05).(4) The concentration of ET-1 in umbilical vein blood of controls was(55.70±10.45) pg/ml.The concentration of ET-1 in umbilical vein blood of FGR was(75.24±8.83) pg/ml,which is higher than the concentration of controls.The difference was statistically significant(P＜0.01).(5)In control group,the concentration of ANP in umbilical vein blood was higher than the concentration in elbow vein blood(P＜0.05),the concentration of ET-1 in umbilical vein blood was lower than the concentration in elbow vein blood(P＜0.05).(6)In FGR group,both the concentration of ANP and ET-1 in umbilical vein blood was significantly higher than the concentration in elbow vein blood(P＜0.01).(7)The ANP/ET-1 ratio in elbow vein blood of controls was(1.98±0.43).The ANP/ET-1 ratio in elbow vein blood of FGR group was(1.33±0.73),which is lower than the ratio in controls.The two groups had statistic significant difference(P＜0.01).(8)The ANP/ET-1 ratio in umbilical vein blood of controls was(2.62±0.43),the ANP/ET-1 ratio in umbilical vein blood of FGR was(1.59±0.85),which is lower than the ratio in controls.The difference was statistically significant(P＜0.01).(9)In controls,the ANP and ET-1 in elbow vein blood of controls and in umbilical vein blood were positive correlated with the birth weight of neonates(r=0.459,r=0.790,r=0.608,r=0.792).(10)In FGR,the ANP in elbow vein blood and in umbilical vein blood were positive correlated with the birth weight of neonates(r=0.470,r=0.501),the ET-1 in elbow vein blood and in umbilical vein blood were negative correlated with the birth weight of neonates(r= -0.868,r=-0.848).The ANP/ET-1 in elbow vein blood and in umbilical vein blood were positive correlated with the birth weight of neonates(r=0.675,r=0.674).Conclution:It showed that the significantly reduced concentration of ANP and ANP/ET-1 ratio and increased concentration of ET-1 had important effect on FGR.The two hormones may be the new indicater of predicting FGR.Increasing the concentration of ANP in the uteroplacental blood flow and enlarging the ANP/ET-1 ratio,may be a new route of preventing and treating fetal growth restriction.