Relationship Between The Expressions Of CDK2,p27kip1 Proteins And Non-small Cell Lung Cancer Of XuanWei

Objective:To study the expressions of CDK2 and p27kipl protein in non-small cell lung cancer of Xuanwei.To explore their relationship and biological behavior of lung cancer of Xuanwei.Methods:30 cases non-small cell lung cancer tissues and normal pulmonary tissues of Xuanwei were selected as the experimental group.30 cases non-small cell lung cancer tissues and normal pulmonary tissues of other regions were selected as the control group.Immuneohistochemical method was used to detect the expressions of CDK2 and p27kipl protein in lung cancer tissues and normal pulmonary tissues. SPSS12.0 statistic package was applied to analyze the data(x~2test and PEARSON Correlatons).Results:The expressions of CDK2 protein were situated in endochylema of lung cancer tissues.The positive expression of CDK2 protein was 73.33%in lung cancer tissues and 10%in normal pulmonary tissue of experimental group.There was a significant difference between lung cancer tissues and normal pulmonary tissues of experimental group(P＜0.05).The positive expression of CDK2 protein was 53.33% in lung cancer tissues and 3.33%in normal pulmonary tissues of the control group. There was a significant difference between lung cancer tissues and normal pulmonary tissues of control group(P＜0.05).The expressions of CDK2 protein in lung cancer tissues had not significant difference between the experimental group and the control group(P＞0.05).The expression of CDK2 had no correlation with clinical stage and the differentiation(P＞0.05).The expressions of CDK2 protein had a correlation with histopathology type of the experimental group(P＜0.05).The expressions of CDK2 protein had significant difference between adenocarcinomas of the experimental group and adenocarcinomas of the control group(P＜0.05).The expressions of p27kipl protein were situated in endochylema of the experimental group and control group.The expressions of p27kipl protein were mainly situated in bronchial epithelium mucosae and alveolar epithelial cells of normal lung tissues.The expressions of p27kipl protein in normal lung tissues were more than those in lung cancer tissues.The positive expression of p27kipl protein was 36.67%in lung cancer tissues and 90.00%in normal pulmonary tissues of the experimental group.There was a significant difference between lung cancer tissues and normal pulmonary tissues of experimental group(P＜0.05).The positive expression of p27kipl protein was 43.33%in lung cancer tissues and 93.33%in normal pulmonary tissues of the control group.There was a significant difference between lung cancer tissues and normal pulmonary tissues of control group(P＜0.05). The expression of p27kipl had no correlation with clinical stages,the differentiation and histopathology type of non-small cell lung cancer(P＞0.05).The expressions of CDK2 and p27kipl proteins in patients with lymph node metastasis were significantly different from those in patients without lymph node metastasis(P＜0.05).There was negative correlation between the expressions of CDK2 and p27kipl protein(P＜0.05, r=-0.484,r=-0.530).Conclusions:The high expression of CDK2 protein and the low expression of p27kipl protein in non-small cell lung cancer might play an important role in carcinogenesis of lung carcinoma of Xuanwei.The expressions of CDK2 protein had correlation with histopathology type of Xuanwei.The expressions of CDK2 protein in adenocarcinomas tissues had significant difference between Xuanwei and the other regions.The expressions of CDK2 and p27kipl proteins had correlation with lymph node metastasis.There was negative correlation between the expressions of CDK2 and p27kipl proteins in lung cancer tissues.