The Clinical Research Of Efficacy Of Celecoxib And Gabapentin In The Control Of Postoperative Pain After Laparosopic Surgury Patients

Objective To observe the effect and the safety of the Celecoxib and Gabapentin as the analgesic after laparoscopic surgery patients.Methods 90 cases of laparosopic surgery patients were selected,they were undergoing the operation of cirsocele high ligation and direct hernia neoplasty.They were all male,18～40 years old,50～70kg weight,ASAⅠ-Ⅱ, and divided into three groups randomly.One was Celecoxib group(groupⅠ), one was Gabapentin group(groupⅡ)and the other was control group(groupⅢ). Celecoxib and Gabapentin were used as postoperative analgesics in the experiment group(groupⅠand groupⅡ)and the rest in the control group.The administration of Celecoxib was as following:2 capsules(200mg/each)were taken orally at 8～12 hours before surgery,and then 1 capsule was taken at 6 hours after operation when patients could eat food.Celecoxib was administered 1 capsule twice a day(in the morning and evening)in the first and the second surgery day.The administration of Gabapentin was as following:8 capsules(100mg/each)were taken orally at 8～12 hours before surgery,and then 4 capsule was taken at 6 hours after operation when patients could eat food. Gabapentin was administered 4 capsule thrice a day(in the morning,noon and evening)in the first and the second surgery day.The administration of placebo was the same to groupⅠ.The VAS score at 30min after recovering,at 6h,12h, 24h,48h,72h after operation was observed and recorded,adverse reaction was observed everyday,grade the sleep satisfaction of the patients on the evening of operation,and the vital signs were observed and recorded at 8h before the operation,at 30min after recovering,at 6h,12h,24h,48h,72h after operation.Results(1)General state of health of the patients(age,body weight and so on)among three groups showed no significant difference(P＞0.05).(2)The effect of analgesia:Ⅰ,Ⅱ,Ⅲtheree groups were tested by analysis of variance, the outcome showed significant difference at 30min after recovering and 6h after operation,no significant difference at 12h,24h,48h,72h after operation.So three groups were tested by SNK q at 30min after recovering and 6h after operation. 30min after operation,VAS=1.47±1.06 ofⅠ,VAS=1.51±1.08 ofⅡ, VAS=3.12±1.68 ofⅢ.6h after operation,VAS=1.69±1.12 ofⅠ, VAS=1.62±1.10 ofⅡ,VAS=2.52±1.32 ofⅢ.ComparedⅠandⅡ,two groups showed no significant difference(P＞0.05),ComparedⅠ,andⅢ,two groups showed significant difference(P＜0.05),ComparedⅡ,andⅢ,two groups showed significant difference(P＜0.05).(3)Sleep quality:the sleep satisfaction of the patients,score(1.43±0.82)inⅠ,score(1.17±0.75)inⅡ,score(2.77±0.57)inⅢ.After statistical analysis,ⅠandⅡshowed no significant difference(P＞0.05),ⅠandⅢshowed significant difference(P＜0.05),ⅡandⅢshowed significant difference(P＜0.05).(4)Vital signs:three groups showed no significant defference(P＞0.05).(5)Adverse reaction:no adverse reaction inⅠ,Ⅱ.In Celecoxib group,nausea and vomiting(2 persons);abdominal distention(1 person).In Gabapentin group,nausea and vomiting(0);abdominal distention(1 person).In control group,nausea and vomiting(1 person);abdominal distention(1 person).Three groups showed no significant difference(P＞0.05).Conclusion Celecoxib has a satisfactory effect and safety using in postoperative analgesia in laparoscopic surgery patients.There was few adverse reaction,good sleep satisfaction,the stable vital signs.They can suppress the stress reaction effectually and suit to treat the pain after laparoscopic surgery patients.