Clinical Effect Analysis Of Gabapentin With Continuous Femoral Nerve Block In Multimodal Analgesia Methods For Postoperative Pain Management After Total Knee Arthroplasty

Objective Total knee arthroplasty (TKA) in the adult patientpopulation is a prevalent surgical procedure. In pain after TKA is oftensignificant and can be very difficult to manage and treat for both medicaland nursing staff. This article is to compare the analgesic effects ofGabapentin with Continuous Femoral Nerve Block plus multimodalanalgesia (experimental group)with normal multimodal pain controlledanalgesia(control group)after total knee arthroplasty，and evaluate the kneefunction with six months following up.Methods From October2011to October2013，48patientsundergoing unilateral total knee arthroplasty were randomly devided intotwo groups，24cases for each(n=24). Besides the Gabapentin used afteroperation12hours,there was no difference of pain management betweenexperimental group and control group. In the perioperative period, Rest,Passive and Initiative Visual analogue scale(RVAS,PVAS,AVAS)were usedto evaluate perioperative pain. The range of motion(ROM) andcomplications were observed and recorded. All the patients werefollowed up for6months, Knee Society scoring system (KSS)was used toassess knee function.Results In48hours postoperative resting state，pain score(VAS)of experimental group was significantly lower than that of control group(P<0.001)．Adverse reactions and ROM after6months were no significantdifference(P＞0.05）.Conclusions Gabapentin and continuous Femoral Nerve Blockcombined with multimodal analgesia has better early analgesic effect fortotal knee arthroplasty，especially in48hours after surgery, and feweradverse reactions was observed, which provides faster postoperative kneerehabilitation．Therefore，it should be considered a better analgesia methodfor patients after total knee arthroplasty．...