Clinical Research On Modified Peach Kernel For Activating Qi Decoction In Treating Insulin Resistance In Gerontism Diabetes Mellitus (Deficiency Of Both Vital Enegy And Yin, Obstruction Of Collaterals By Blood Stasis)

Objective:the study discusses gerontism diabetes mellitus of insulin resistance apply modified peach kernel for actixratlng qi decoction,and observes state of insulin resistance and clinical symptom by discussing gerontism diabetes mellitus' pathogenesy of TCM and western medicine combined determination of treatment based in pathogenesis obtained through differentiation of symptoms and signs.It analyzes mechanism of action of the decoction in order to reclamate the new way to treat gerontism diabetes mellitus by traditional chinese medicine.Methods:60 samples of elderly diabetes patients are divided into two groups(the treatment group and the control group)according to the simple random device,each group consisting of 30 samples.Two group both take Sulfonylureas(Glimepiride or Gliclazide or Glipizide)and Biguanides (Metformin)。In addition to the therapy of the control group,the treatment group take eight pills of Sanhuang pills to lower blood glucosⅠ/Ⅱ号(basic compose of medicine:Astragalus hoangtchy,semen persicae,cassia twig,rhubarb,radix et rhizoma rhei/prepared radix et rhizoma rhei,mirabilitum dehydratum,Radix Ophiopogonis,metropolis,liquorice)each time,three times a day.One course of treatment lasts four weeks.The researcher will observe and document the patients' general conditions,specific laboratory index and their levels of blood glucose and insulin,and symptom of traditional Chinese medicine, calculating IAI and HOMA-IR.The researcher will also observe the characteristics of elderly diabetes and analyzes the effect of altered Taohe chengqi decoction on reducing insulin resistance and its clinical symptoms. Results:1.Of the two groups of 60 samples,there are 55 samples of dyslipidemia,56 of glycosylated hemoglobin abnormalities and 36 of insulin resistance,91.67%,93.33%and 60%of the total respectively.2.The treatment group is significantly improved in fasting blood glucose,postprandial 2h blood glucose,fasting insulin,IAI,HOMA-IR(P＜0.05).Among them,There was a significant difference between the two groups in postprandial 2h blood glucose,fasting insulin,IAI(P＜0.05).3.The success rate of lowering blood glucose in the treatment group is 86.67%,and the success rate of decreasing peripheral insulin resistance is 83.3%(with a reversal rate of 23.3%);The success rate of lowering blood glucose in the control group is 76.67%,and the success rate of decreasing peripheral insulin resistance is 56.67%(with a reversal rate of 10%):there was no significant difference on lowering glucos between the two groups in either of the two treatments above(P＞0.05);there was a significant difference on improving insulin resistance between the two groups in either of the twotreatments above(P＜0.05).(4)The success rate of improving clinical symptoms in the treatment group is 93.33%,in the control group is 70%and there was a difference between the two groups(P＜0.05).Conclusion:1.the elderly diabetes patients commonly have the symptoms of increasing blood lipids,inability of controlling blood glucose and insulin resistance.2.using modified peach kernel for actixratlng qi decoction and take Sulfonylureas and Biguanides in therapy can lower blood glucose and improve insulin resistance,partially increase reversal rate,and significantly reduce the clinical symptoms of the elderly diabetes.