Study On Correlation Between TCM Syndromes Of KOA And The Level Of NO And TGF-β1

Objective:To study the Correlation between the clinical manifestation of TCM Syndromes of Knee Osteoarthritis and the level of Nitric oxide(NO)and Transforming growth factor -β1(TGF-β1)in modern medicine,further inquires into its cause of disease pathogenesis.In order to inherit and innovate the standard of clinical standard,to enhance the level of Syndrome Differentiation and Treatment of KOA and curative effect to provide the new objective reference,then to optimize the Knee Osteoarthritis surgery and the non-surgery therapeutic schedule,reduces the society,the family serious economy,the spiritual burden and improves the patient quality of life to contribute a strength..Materials and method:study object for Guangdong Province Chinese medicine hospital Zhuhai Hospital orthopedics outpatient service and in hospital patient.The standard of diagnoses according to TCM Syndromes of Knee Osteoarthritis,From integrates with manifestation of the kidneys-marrow deficiency(1 group)separately and the blood stasis(2 groups)of Knee Osteoarthritis patient each 40 examples to do for the observation group.In addition is equipped with the normal healthy persons(above 45 years old)40 examples to make the control group(3 groups).Extracts the venous blood strictly according to the laboratory examination target establish requirements before and after treatment.Examine the target of Nitric oxide (NO)and Transforming growth factor -β1 in the specimen,And analyze the obtained data with SPSS13.0 for the Windows,the group compares,when(P＜0.05)The difference has statistics significance.Results:Before treatment,the level of Nitric oxide(NO)of two Observer Group is significantly higher than the control group's(P＜0.01),and blood stasis group is higher than kidneys-marrow deficiency group(P＜0.01).But the level of transforming growth factor-β1(TGF-β1)was significantly lower than that of the control group(P＜0.01),and blood stasis group is lower than kidneys-marrow deficiency group(P＜0.01);Compared NO and TGF -β1 among the three groups,all P values of statistical analysis are less than 0.05 (P＜0.05),The inter-group difference between the groups was significant. After treatment,the level of NO of two Observer Group is significantly lower than that before treatment(P＜0.01),and blood stasis group was higher than that kidneys-marrow deficiency group(P＜0.01);The level of TGF-β1 is higher than that before treatment(P＜0.01),and blood stasis group is lower than kidneys-marrow deficiency group(P＜0.01);NO and TGF-β1 in 1,2 comparative analysis between the two groups,the P values are less than 0.05(P＜0.05), The difference between the groups was significant.Conclusion:This study results show that nitric oxide(NO)and transforming growth factor -β1(TGF-β1)changed significantly in the disease process of Knee Osteoarthritis,The level of NO and TGF-β1 has relevance with knee osteoarthritis.After treatment,The level of NO and TGF-β1 has changed,its treatment may acts by the change of NO and TGF-β1 levels to a certain extent,The TCM Syndromes of Knee Osteoarthritis(blood stasis,kidneys-marrow deficiency)has certain relevance with Nitric oxide and Transforming growth factor -β1(TGF-β1).Before and after treatment, the changes of NO and TGF-β1 level in TCM Syndromes of Knee Osteoarthritis (blood stasis,kidneys-marrow deficiency)are statistical significant differences.This is positive for further clinical study of Chinese medicine in knee osteoarthritis treatment,and to provide an objective observation of the indicators as well,It is helpful'for TCM Syndromes of Knee Osteoarthritis and to provide micro-indicators,Meanwhile observing the level change of NO TGF-β1 in The drug research and clinical treatment of osteoarthritis is also a certain level of significance.