The Observation Of The Clinical Curative Effect With Taxanes Combined With Platinum Chemotherapy (TP/PT/PC) In Epithelial Ovarian Carcinomas (EOCs)

Objective Through retrospective analysis, observation taxanes combined with platinum chemotherapy(TP /PT /PC) in Epithelial Ovarian Carcinomas(EOCs) clinical curative effect, preliminary discussion after TP chemotherapy treatment the EOCs survi -val prognosis influence factors. Methods The clinical data and follow-up data of 90 epith -elial ovarian carcinomas who were treated in our hospital from January 2004 to October 2007 were retrospectively studied. The Kaplan-Meier method, log-rank test and the COX proportional hazards regression model were used to identify prognostic factors. Results TP regimenis:paclitaxel 135mg-175mg/m2 (d1) or docetaxel 75mg/m2(d1) and platinum 60-80mg/m2 (d2)or carboplatinum (AUC): 5.0 (d2) or oxaliplatin130mg/m2 (d2) iv, 21-28 day is one cycle, completed 4 cycles at least.the curative effect could be observed. (1)In induced treatment of TP:early-stage and advanced EOC had the response rate were 100.00% and77.55% ,respectively. the total RR was 81.97%(50/61). In the second treatment: It is 80.00% that the early ovarian cancer group is efficient (4/5); It is 54.17% (13/24) in the advanced ovarian cancer The total RR was 58.62%(17/29). (2) side effects of the TP therapy were tolerated .The incidence of gradeâ…¡orIII, IV bone marrow depression was 51.11% and6.67%, respectively. The gastro-intestinal tract response formation rate 51.11% (46/90), periphery the neuritis (joint, muscle ache, refers to foot end paraesthesia and so on) the formation rate 51.11%(46/90). The flush incidence of complexion is 33.33% (30/90), the slight liver work damages about 16.67% (15/90). allergic response about 2.22%.There is no serious chemotherapy poisonous side reaction. (3).The median survival of 90 patients with epithelial ovarian carcinoma was20.50 months. good cytoreductive surgery (no residual or residual<2.0cm) was performed to 77 patients and their survival rate was significantly higher than these of 13 unsuccessful cases (residual>2cm).prongosis could not be significantly influenced by Clinical stage, pathological types, cellular grade, postsurgerical had chemotherapy intervals .(P >0.05). first or second treatment ,size of residual, the sensitivity of platinium with ROC, and the clinical response of TP, the Disease-Free Interval(DFI) with ROC were proved to be independent prognostic factors by COX proportional hazards regression model. COX multiple factors analysis confirmed that the prognostic factors of EOCs were related to the Disease-Free Interval (DFI) with ROC. Conclusion Taxanes combined with platinium chemotherapy treated 90 EOCs showed Tp regimen had a good clinical response and less side-effects . TP chemotherapy is an effective and well tolerated regimen.It was recomm -ended as the first-line chemotherapy regimen for patients newly diagnosed stage II,III or IV postoperative EOCs,and also was suitable for the platinum-sencitived ROC.Cox proportional hazard model confirmed that the prognostic factors of EOCs were related to tumor residual after primary surgery, the sensitivity of platinium with ROC, and the clinical-response of TP, the Disease-Free Interveal(DFI) with ROC sencitive with platinum chemotherapy. And the independent prognostic factors by COX proportional hazards regression model proved was the Disease-Free Interveal(DFI) with ROC sencitive with platinum chemotherapy.