The Expression And Clinical Significance Of Soluble Mhc-I Chain Related Protein A In Kidney Allograft Recipents

Objective: To investigate the expression and clinical significance of soluble major histocompatibility complex class I chain-related protain A(sMICA)in kidney allograft recipients. Method:We investigated the serum levels of sMICA of 42 de-novo renal transplant recipients,monitoring negative immune event and allograft function. Result:(1) Soluble MICA levels were detected in the serum of 30 (71.43%)renal transplant recipients and 2(10.00%)control group patients(P=0.000).(2) Clinical analysis showed that only 3 out of 30 patients (10.00%)of sMICA positive group developed a acute episode of rejection,however,6 out of 12 patients(50.00%)of sMICA negative group developed a acute episode of rejection(P=0.009). There is no statistic significance of the episode of accelerate rejection and DGF between sMICA positive group and sMICA negative group.(3) The serum creatinine levels of sMICA positive group patients was lower than sMICA negative group patients at time point of 3 month,6 month and 12 month(P value was 0.000,0.001 and 0.000,respectively).exclusing the negative impact of acute rejection for allograft function,The serum creatinine levels of sMICA positive group patients was remain lower than sMICA negative group patients(P<0.05).Conclusion:The stress procedure of kidney transplantation can induce the expression of sMICA.The acute rejection rate of sMICA positive group patients was lower than that of negative group patients.It is showed that sMICA did protection to kidney allograft,it was independent to the negative impact of acute rejection for allograft function.