Clinical Study On Treatment For Iron Deficiency Anemia With The Application Of "Spleen-hematosis" Theory By Prof. Shilin Huang

ObjectiveTo summary the academic thought on "spleen-hematosis" theory of Prof.Shilin Huang and to study the relationship between iron deficiency anemia(IDA)and chronic gastritis by the etiological analysis of IDA.Through treating IDA with Buxue capsule which was developed by Prof.Shilin Huang,to observe the clinical efficacy of "spleen-hematosis" theory,also to further explore the rationale of it and together to establish a new standard on the treatment for IDA with the merits of high performance, innocuity,convenient and treating mainly by traditional Chinese medicine.methodsThe pathogeny of 143 patients was analyzed.60 patients with IDA and chronic gastritis who were together with blood deficiency syndrome of spleen deficiency type were divided into two groups randomly,30 patients in each group.Patients in research group were treated with Buxue capsule.Patients in control group were treated with FeSO₄.The courses of treatment in two groups were both 6 weeks.The indexes were observed and analyzed,which included the changes of symptom-complex,total effective rate of treatment,hemogram,myelogram,serum iron(SI),serum ferritin(SF), total iron binding capacity(TIBC),transferring saturation(TS),infection rate of helicobacter pylori(HP),gastric mucosa,acidity total of gastric juice and Pepsase activity.It was given a mark or compared with pretherapy and control group.The results were analyzed statistically by SPSS 11.5.ResultsIt was estimated in symptom-complex of 60 patients.The total effective rate was 96.67%in research group and 70%in control group.There were obvious improvements in all syndromes in research group.There were significant differences between two sets (P＜0.05).In the therapeutic effect of IDA,the total effective rate was 96.67%in research group and 80.00%in control group.The differences between two sets were significant(P＜0.05).The results of hemogram in each group showed that the cell population of red blood cell,the content of hemoglobin and the hematocrit all had been heighten in different degree.But It was better in research group than in control group(P＜0.01).The results of hemogram,myelogram,iron in exterior-cellular and interior-cellular appeared that it had been improved in each group in different degree.It was better in research group than in control group(P＜0.05).It was also appeared that SI,SF and TS had been ascended and TIBC had been descended in both groups.But It was better in research group than in control group(P＜0.05).There were improvements in both groups in endogastritis,anaemia of gastric mucosa,infection rate,acidity total of gastric juice,and Pepsase activity in post-treatment.But It was better in research group than in control group(P＜0.05).The results of side effect showed that there were apparent side effects by 9 patients in control group and no side effects in research group in the whole course.Conclusions1.The value of the clinical application of "spleen-hematosis" theory on hematology is reflected by the treatment for IDA by Buxue capsule.And it has achieved the goal of treating disease with searching for etiological factor.2.The therapy function for IDA of Buxue capsule is better than FeSO₄.It can retrieve anemia and gastritis with shorter time,higher-performance.There are few side effects in the course of treatment.It's a safe,effective and practical method of traditional Chinese treatment for IDA.3.Chronic gastritis is one of the most major causes of IDA and there are some internal associations between them.