Investigation Of Plasma TPS In Lung Tumor's Diagnosis And Surgical Treatment

Objective: To explore the feasibility of detecting the TPS level using plasma sample, and the significance of the plasma TPS level in the diagnosis and treatment of lung tumor.Method: 20 healthy human plasma(heparin prevents clotting) and serum levels of the TPS were measured by enzyme linked immunosorbent assay (ELISA); 63 cases suffering lung tumor were included, whose plasma levels of TPS were measured at the first day and 14 days after surgery. The Cut-off value of preoperative plasma TPS was determined by using the ROC curve, serum CEA levels as plasma TPS control.Result:1 There is no significant difference between plasma and serum levels of the TPS in healthy people(P>0.05).2 The plasma TPS levels in lung cancer patients are obviously higher than that in lung benign tumor patients (P<0.001), when the Cut-off value is 151 U/L, the sensitivity and specificity of lung cancer diagnosis are 85% and 80% respectively; When the serum CEA normo-reference value is 0～5ng/ml, the sensitivity and specificity of lung cancer diagnosis are 30% and 97% respectively. There exists significant diference in sensitivity of diagnosising lung tumor using plasma PTS and serum CEA respectively(P<0.005), the contrast of specificity have no significant diference(P>0.05).3 Compared with the healthy people, the plasma TPS levels in lung benign tumor patients are significantly higher(P<0.01).4 In the group of lung benign tumor patients, the contrast of plasma PTS between pre-operation and post-operation has no significant diference (P>0.05).5 After complete resection, The chang of lung cancer patients's plasma TPS level is significantly difference(P<0.01). 6 The plasma TPS levels of TNMⅢstage lung cancer patients are relatively higher than that inⅠandⅡstage, the plasma TPS levels of patients with lymph node metastasis(N1,N2) are relatively higher than that in patients without lymph node metastasis. However, both comparisons have no significant difference (P>0.05).7 The plasma TPS levels of exploratory thoracotomy and palliative resection lung cancer patients are significantly higher than that in complete tumor resection patients (P<0.05), After the surgery the chang of the plasma TPS level is relatively non-obvious.Conclusion:It is feasible to detect the levels of the TPS using plasma (heparin prevents clotting) as samples; Plasma TPS levels of preoperative lung tumor patients are meaningful for the diagnosis, better than using serum CEA; Measuring plasma TPS of postoperative patients with lung cancer may help judge the operation effect; It's useful to judge the effect of operation when measuring plasma TPS levels of lung cancer patients after operation.