A Clinical Study On The Regional Postsystolic Shortening In Coronary Artery Disease Patients By Strain Rate Imaging

Objective: To assess postsystolic shortening ( PSS) and it's clinical meanings during isovolumic relaxation phase in regional myocardium of coronary artery disease patients and normal persons.Methods: Left ventricular regional myocardium of 30 coronary artery disease patients (confirmed by coronary angiography) and 17 non-cardiac disease subjects (control group) was assessed by strain rate imaging,TDI was performed in the apical views(four chamber,two chamber,and long axis)for the long axis motion of the left ventricular.TDI cine loops containing two consecutive cardiac cycles were stored digitally for post-processing. left ventricular myocardial strain and strain rate were acquired along long axis asynchronously in different walls , peak systolic strain rate ( SRs ),early filling ( SRE ),the lasting time of postsystolic shortening (Tpss ),postsystolic strain(εpss ) in regional myocardium were measured.According to the results of coronary angiography and 17 left ventricular segment model, left ventricular myocardium of coronary artery disease patients were divided into ischemia segment and non-ischemia segment.adding the control group, the total number is three.the parameters of different groups were compared, the correlation between the regional SR PSS and it's regional EF was performed by correlation analysis.Results: pathologic PSS presented in ischemia segment; compared with physiologic PSS, pathologicεpss during isovolumic relaxation were bigger than physiologic(P < 0. 001);pathologic TPSS were longer than physiologic(P < 0. 001);but pathologicεS were lower than physiologic(P < 0. 001); the values of EF in regional myocardium which presented PSS were significant lower than those which not presented.Conclusions: Physiologic PSS are different f rom pathologic PSS. Strain and strain rate can be useful in understanding mechanism of PSS and guide clinical diagnosis and therahpy...