The Empirical Study Of Modified Frontolateral Partial Laryngectomy Without Tracheotomy

Objective:To build an animal model in order to investigate and to highlight new developments in the treatment of early true vocal cord cancer with modified frontolateral partial laryngectomy without tracheostomy. Methods:To measure the areas of 6 canines` excised larynges in the following states: initial state; after modified frontolateral partial laryngectomy without tracheotomy and with the cartilage closed; after modified frontolateral partial laryngectomy without tracheotomy and with the cartilage open. Comparing the data of all 6 canines in order to establish the theoretical model to confirm the feasibility of modified frontolateral partial larnygectomy without tracheotomy. To measure the areas of 6 canines` larynes in the following states: after right chordectomy with laryngofission; after modified frontolateral partial larnygectomy without tracheostomy; after enlarged modified frontolateral partial larnygectomy without tracheotomy. Comparing the data of all 10 canines in order to confirm the feasibility of modified frontolateral partial laryngectomy without tracheotomy in vivo.Results:Ex vivo group: The areas of 6 canines` excised larynx in initial state and areas of 6 canines` excised larynx after modified frontolateral partial laryngectomy without tracheotomy and with the cartilage closed showed significant deviation(t=5.74 P<0.05). The areas of 6 canines` excised larynx in initial state and areas of 6 canines` excised larynx after modified frontolateral partial laryngectomy without tracheotomy and with the cartilage open showed no significant deviation(t=2.47 P>0.05). In vivo group: All the experimental animals were alive for 48 hours except one which was killed by anesthesia. No experimental animal suffered from dyspnea, except the one which was killed by anesthesia. The areas of 10 canines` larynges in initial state and the areas of 10 canines` larynges after right chordectomy with laryngofission showed significant deviation(Q=0.047 P>0.05); The areas of 10 canines` larynx in initial state and areas of 10 canines` larynges after modified frontolateral partial laryngectomy without tracheotomy showed no significant deviation(Q=8.74 P>0γ.05); The areas of 10 canines` larynx in initial state and areas of 10 canines` larynges after enlarged modified frontolateral partial laryngectomy without tracheotomy showed significant deviation(T= 40.00 P<0.05); Conclusions:Modified frontolateral partial laryngectomy without tracheostomy is an expeditious and highly successful means of eradicating early and selected invasive glottic squamous cell carcinomas,which is proved by animal experiment.