The Research On Prof. Li Fuyu's Clinical Experiences In Treating Osteoarthritis

The research is devided into two parts: summing-up of Prof. Li Fuyu's clinical experiences in treating knee osteoarthritis and treating osteoarthritis with the method of Detoxificating and Invigorating the Kidney.Summing-up of Prof. Li Fuyu's clinical experiences: the academic thoughts includes four aspects: correspondence principle of nature and human being, focusing on integrated and lasting motivation; weakness benefiting, being good at geriatric medicine; set forth his views based on toxin, being good at difficulties and vital diseases; stick to traditional Chinese medicine and reference to Western medicine.The clinic experiences: by summing-up the etiology and pathogenesis, differentiation of syndromes and the clinlical thoughts, the author explained the tutor's viewpoint that deficiency of liver and kidney and congestion of toxin and blood is the basic pathogenesis of osteoarthritis, and displayed completed the tutor's clinical thoughtsand drug administering characteristics.The clinical research: treating osteoarthritis with the method of Detoxificatingand Invigorating the Kidney is based on the clinical experiences of Prof. Li Fuyu. The purpose is to observe the curative effects and the functional mechanism of Detoxificating and Kidney-Invigorating Pill. The method is to compare the Detoxificating and Kidney-Invigorating Pill improving blood circulation and detoxicating, and liver & kidney benefiting with Viartril-S. 60 osteoarthritis patients recognized as deficiency of liver and kidney and congestion of toxin and blood were divided randomly into two groups. The test group took orally Detoxificating and Kidney-Invigorating Pill the control group took Viartril-S Capsule, both for 8 weeks. The therapeutic and security effects were observed through the international WOMAC questionnaire, visual analogue scale (VAS), traditional Chinese medicine symptoms quantitative evaluation, the serum level of MMP-3 and TIMP-1, and so on. The results reveal that in the test group, the treatment shall decrease the WOMAC index, squat pain score and score of Traditional Chinese medicine symptoms evidently, lower the MMP-3 level in serum while increase the TIMP-1 level, with no distinctive differences contrast to the control group; however, there are distinctive differences on the improvement of the Traditional Chinese medicine symptoms between the test group and the control group. There's no distinctive difference between the tow groups in security indexes. The results reveal that both the Detoxificating and Kidney-Invigorating Pill and Viartril-S Capsule can improve the symptoms of osteoarthritis effectively, and two kinds of medicine have equal therapeutic effects. But as far as the improvement of Traditional Chinese medicine symptoms are concerned, the Detoxificating and Kidney-Invigorating Pill is superior to Viartril-S Capsule. The regulation of the serum level of MMP-3 and TIMP-1 may be one of the mechanisms of therapeutic effects.