| PES is a kind of polymer membrane material that has excellent comprehensive performance, which is usually used to prepare ultrafiltration membrane. Also ,it has excellent biocompatibility, good hydrophilicity, and its surface is smooth. So it can reduce the protein adsorption layer which is formed on the membrane surface of the side of the blood, and it is difficult to bring forth adverse reactions such as blood coagulation ,hemolysis, and so on . So it is a good kind of dialysis membrane material. However, the clearance rate of the existing PES membrane to middle Molecular is not ideal.In this thesis, PES hollow fibers are fabricated using dry-wet phase inversion method. The effects of the dope solution composition, bore fluid composition and the take-up speed, the air gap, the thick of membrane wall, the inner diameter of membrane on the membranes morphology and performance have been investigated experimentally. Excellent performance membrane were chose to seal dialyzer and did simulation dialysis experiments for investigating clearance rates of Lysozyme ? urea and rejection of bovine serum albumin(BSA) of dialyzer.The results showed that membranes morphology structure became denser with an increase of PES concentration, which lead to pure water permeation fluxes and clearance rates of Lysozyme decreased while break pressure ,rupture mightiness,the rate of draw elongation increased, and rejection of bovine serum albumin(BSA) all above 98%; the water flux and clearance rates of Lysozyme while the polyethylene glycols (PEG) additive increased, and rejection of BSA, the break pressure decreased; The morphology structure of membranes became looser while the content of DMAc increased in the bore fluid, and it can be observed macrovoids by SEM while solvent content reached 80% in the bore fluid. As a result, the water fluxes and clearance rates of Lysozyme increased, and clearance rates of Lysozyme reached to 88%, and the rejection of BSA all above 97%, and break pressure of membranes reduced; Water flux and clearance rates of Lysozyme decreased as the air gap increased, the effect of air gap on the rejection of BSA and break pressure were negligible. As the take-up speed increased the tropism of membranes increased, as a results, water fluxes and clearance rates of Lysozyme decreased, while the rejection of BSA and break pressure of membranes increased; Water flux and clearance rates of Lysozyme decreased as the thick of membrane wall increased while rejection of BSA and break pressure increased, while the inner diameter of membrane increased had a contrary trend to the thick of membrane; In the simulation dialysis experiments, and it had a good the clearance rate of Lysozyme and urea ,and the rejection of the BSA was perfect. |
