Research Of High Biocompatibility Polyethersulfone(PES) Hollow Fiber Hemodialysis Membrane

Some patients with renal dysfunction often need hollow fiber membrane artificial dialyzer get rid of the harmful substances and water in blood, and adjust human body electrolyte. During the hemodialysis, blood corpuscle and albumen in the blood easily bring in descending membrane flux, and so in future the main researched orientation is to find a new type dialyze membrane ,which is not prone to adsorb albumen and form congregating albumen layer, and have a smooth membrane surface. Nonce materials of dialyzing membrane are getting rid of the stale and bringing forth the fresh, yet the removal of β₂-MG and biocompatibility still have shortcomings. This study focuses on the configuration performance and dialyze performance of polyethersulfone (PES) membrane material.In this paper, dry-wet spinning process is used for spinning PES hollow fiber dialysis membrane, and the structures of different thickness and diameter of the hollow fiber membrane and the dialysis performance of the developed dialyzer are researched, so as to determine the best spinning process; Area of the dialysis membrane and analysis solution and simulation solution flow and solute concentration gradient of liquid are also researched which affect on membrane dialysis performance, and then determine the optimal conditions for dialysis.The dealed hollow fiber membranes are cast into group pieces, and test the water flux, breach pressure, elongation, and break press using laboratory-made devices. Using centrifugal casting method, hollow fiber membrane is encapsulated into dialyzers, and prepared by the water, urea, Lysozyme and BSA simulated liquid form, which uses Lysozyme instead of β₂-MG, BSA instead of human serum albumin. In this paper, the simulation solution is used to evaluate dialysis performance of PES hollow fiber membrane dialyzers.The results showed that the addition of PEG additive to 27.6%, the mechanical properties of membranes is better. As hollow fiber membranes thickness are different, yet urea clearance rate in simulation solution is relatively high, which can reach more than 64% and little difference among them; the BSA have a relatively high rejection, which can be achieved over 98%. There is a certain difference in the Lysozyme clearance rate, the smaller thickness, the higher the rate of removal, and the removal rate of 10μm thickness of the membrane is 29%. The clearance rates of urea were very high using different fiber diameter dialyzers, at around 80%. Urea clearance ratecan reach to the highest 88.6% using 0.26mm fiber diameter dialyzer. The clearance rates of Lysozyme vary greatly, the smaller the diameter, the higher clearance rate, and the highest removal rate of lysozyme is 62.79% using 0.26mm fiber diameter dialyzer. However, there is little impact on the rejection of BSA, which can reach 98%. Increasing dialysis membrane area and enhancing the flow of simulation solution and dialysis solution, and improving solute concentration gradient can increase the clearance rate of urea and Lysozyme, but little affect the rejection of BSA.