The Research On Effect Of Labor Analgesia With Nitrous Oxide On Lactation Of Puerpera

In recent year, people pay close attention to gyneic procreate health along with the improvement of the iatric and living standard , childbirth without pain (CWP) become the thing that the puerpera and the medical staff to follow with interests ,laughing gas CWP is a kind of means that is safe,convenient and effective. Laughing gas is nitrous oxide(N₂O),it is a kind of inhalant paregoric or anesthetic with minimal toxicity . For a long-term clinical research , N₂O can relieve labor pain and to shorten birth process remarkably . The pharmacological action principle of N₂O is inhibit releasing of central nervous system (C.N.S) excitability neurotransmitter and the conduction of nerve impulse and changing ion channel permeability . It can lessen tiredness,anxiety and tension caused by labor pain,It also can lessen the puerpera,s stress reaction and energy consumption .But the problem we were to be faced with is :If it has any effect to the milk secretion about N₂O CWP·Breast milk is the most ideal natural eatables to the infant , it contains sufficient nutritional ingredients and it can easy to be digested and absorbed ,it can inhibit bacteria , it enhances absorption of calcium content , it increases disease resistance , and it is benefits to cerebral neural development,intelligence and physical development, at the same time breast feeding is benefit to mother health . lacteal formation and excrete is a neuroendocrine adjusting process effected by internal secretion,shengli,environment and heredity etc . The concentration of prolactin in blood serum plays a decisive role to milk secretion , Human serum pituitary appendage prolactin is proteohormone that secreted by anterior pituitarium , it plays an important role in starting the milk secretion with the help of estrogen,progestin,corticosteroid and insulin . prolactin in human serum increased gradually during the gestation , it reaches the peak prior to delievery , it increased further during lactation .From this clinical observation we can conclude : CWP has no harmful effect to concentration of blood serum prolactin , it can relieve the ischesis of prolactin , prolactin secretion increases more than before ante partum after post partum 24 hours , puerpera is satisfacted with the childbirth process because using CWP , so they can go with medical staff actively after parturition , Mother and her baby are easy to do premature contact and to suck milk early , it is helpful to colostrum feeding and neonatus development .Objective: to approach the changing of prolactin level in blood serum and the changing of puerperal lactation after appraising the application of N₂O CWP in labor process , it provid some certain clinical evidence for if we can do the breast feeding successfully . Mehtod: to devide 58 vaginal delivery primipara into two groups , one is N₂O group (N₂OG) the other is control group (CG), the primipara in N₂OG inhalat N₂O during labor process , the primipara in CG did not use any anesthetic agent,paregoric . We take vein blood 5ml from the primipara when antepartum (when regularly uterine contraction begins ),post partum 5 minutes and post partum 24 hours , to detect prolactin level in blood serum by radioimmunity , to compare prolactin level of two groups , to compare the Apgar of neonate in two groups , to observe the milk secretion,breast-feeding condition,neonate evacuation and physiological weight lose in two groups at post partum 24 hours,48 hours and 72 hours . Result: It has no significant difference between N₂OG and CG about prolactin level ( P>0.05 ) . It has significant difference between prolactin level of N₂OG and prolactin level of CG after post partum 24 hours ( P<0.05 ) . It has no significant difference between neonate Apgar of N₂OG and neonate Apgar of CG ( P>0.05 ) . It has no significant difference between the begining of milk secretion of N₂OG and the begining of milk secretion of CG , but the milk secretion of N₂OG is more than the milk secretion of CG . The physiological weight lose of N₂OG is lower than the physiological weight lose of CG .Conclusion: N₂O can promote the breast milk secretion after parturition , It has some clinical reference value to help we perform the breast feeding successfully .