Experimental Research About Treatment Of Diabetic Peripheral Neuropathy By Surgical Decompression Of Peripheral Nerves

Objective:Through the study about the treatment of diabetic peripheral neuropathy (DPN) mice by surgical decompression of peripheral nerve, reviewing the method about the mice's nerve conduction velocity, praxiology and pathobiology, we can confirm the sense of surgical decompression of peripheral nerve, and offer the theory for clinically iateria.Methods:We inject the streptozotocin (STZ) to the Wistar mice by peritoneal injection, then we can get diabetes mellitus (DM) mice; and gain DPN mice analogue by using fairly operation, and operate on the DPN mice for preparing the postoperated exemplar, review, record and compare the mice's nerve conduction velocity (NCV), praxiology and pathobiology at designed time.Results:1. Exemplar's general stateThe normal mice's body weight goes to increase gradually, food and drink is commom; the DM mice appear athrepsy, bloom, polydipsia, polyphagia, urorrhagia, the DPN mice and the postoperated mice are similar to the DM mice.2. Exemplar's praxiology scoreThe praxiology score of the DM mice gradually degrate, the DPN mice's appearance is much more conspicuous; the score of the postoperated mice is recovered by the postoperated time increasing.3. Exemplar's nerve conduction velocityThe narmal mice's peripheral nerve's NCV is stable; the DM mice's peripheral nerve NCV step down, and the DPN mice is much more conspicuous; the postoperated mice's peripheral nerve NCV is promoted by the postoperated time increasing.4. Exemplar's pathobiologyObservated by the naked eye, the DM and DPN mice's ischiadic nerve are grosser than the narmal mice; the DM and DPN mice's ischiadic nerve adhere to the amphi-organization; the postoperated mice is much slight. Observated by the microscope, the normal mice's nerve cell is satiate, the arrangement of the nerve fibre is concinnous; the DM mice's nerve cell is swollen, their arrangement is indiscriminate; the DPN mice's nerve fibre is not concinnous, the nerve cell is conspicuous compressed; the postoperated mice's nerve cell is much more concinnous than the DM and the DPN mice.Conclusions:Through injecting the STZ to the Wistar mice by peritoneal injection, and gaining DPN mice analogue by using fairly operation, we can obtain satisfactory exemplar which can simulate DPN's clinical manifestation; The detection of NCV, praxiology and pathobiology proves that surgical decompression of peripheral nerve is an effective way to healing the DPN.