The Study Of Relationship Between Tourette Syndrome And Immunological Function

Tourette syndrome(TS) is a complex of mental illness in children,named by Charcot in 1985.It often onsets in childhood, the main clinical characteristic is abrupt heteronomous mobility tic or sounding.It can complicated with obsessive-compulsive disorder (OCD) or attention deficit hyperactivity disorder (ADHD), and few complicated with Schizophrenia (SCHIZ). Minorities may relieve in adolescence, most of them gradually aggravate,affecting their normal lives and studies.TS can lead to secondary learning difficulties ,personality development questions,social withdrawal and social barriers, those may impact on children's psychological development, can trigger a series of psychological and social problems when they are growing. In recent years, the trend of incidence rate is significantly increasing.The etiology and pathogenesis of this disease is unclear, some scholars believe that it associates with in addition to genetic,the abnormal central neurotransmitter or receptors such factors,also the immunologic abnormity as the potential mechanisms can be explained why a portion of susceptible population has TS. Nowadays the current studies clear that the pathogenes of TS relates to immunity, but the specific relationship and the mechanism has not been cleared.This study was designed to investigate the relationship between Tourette syndrome and immune function, expectating to clear its role in the pathogenesis of TS. We selected children with Tourette syndrome(adopting the third edition Chinese mental disorders Classification and Diagnostic Criteria about the diagnostic criteria of TS) who have visited the pediatric out-patient clinic of the First Hospital of Jilin University betwwen November 2006 and May 2007, a total of 30 cases. 25 cases in Male, 5 cases in female, aged 7-15 years old, with an average age of 10.1±2.7 years old, the course for 1 to 3 years, 2 cases treatment of haloperidol for one year, one case of application Tiapride for six months, others had no drug treatments. At the same time we established the healthy control group of 30 patients, 24 cases in Male, 6 cases in female, aged 7 to 14 years old, with an average age of 10.5±2.1 years old. All children of the former group did not receive hormone therapy and other immunosuppressants. Testing the immune function of two groups, we used scattering turbidimetric method to test IgG, IgA, IgM, C3, C4, applied flow cytometry to test T cell subsets CD3, CD4, CD8.The results show that the differences of IgG, IgA and IgM, Complement four between the two groups have not statistically significance(P> 0.05), But the difference of Complement three between the two groups has statistically significance (P <0.05), and C3 in the patient group is significantly lower than the control group; the differences of T-lymphocyte subsets CD3, CD4, CD8 between patient group and normal control group have statistically significance (P< 0.05), and T-lymphocyte subsets in the patient group are lower than the control group.In sum ,We have conclusions that C3 and T-lymphocyte subsets CD3, CD4, CD8 in the TS patient group are significantly lower than the control group; the differences of between patient group and normal control group have statistically significance,it suggests that TS has relation with human body's immune function.In recent years, a small number of domestic scholars had detected immune globulin, complement and T-lymphocyte subsetsin of TS patients ,the testing and statistical methods were different, the results were not the same. This study's result is different from yan Lu and others's outcome, but given the factors that the small number of cases of this study and the clinical data related, if we can be further research a large sample and increase more detailed study on the clinical data, the conclusions would be more reliable .