| Stagnant blood refers to extravasated blood and blood moving sluggishly in circulation or congested in viscus due to va- rious pathogenic factors including qi stagnation, cold, heat, and phlegm-damp. According to modern medicine, stagnant blood is ascribed to deficiency and sluggishness in blood ci- rculation, including occurrence and development of blood st- agnation and all the subsequent pathogenic processes ass- ociated with blood stagnation. Blood stagnation can be both visible and invisible, including lumps and thrombosis in mus- cle, tissues, and organs caused by abnormal hemorheology and/or inflammation in tissues and organs. Thus blood stag- nation is essentially associated with dysfunction in circulation, changes in hemorheology, abnormality in hemodynamics, im- pairment in connective-tissue metabolism, deregulation in im- munity, inflammatory reactivity, and lipid metabolism, and, in consequence, impairs circulation and microcirculation, leading to myocardial, angina pectoris, cerebral arterial thrombosis, p- neumocardial disease, thromboangiitis obliterans etc.Chinese herbs for activating blood and resolving stasis act through im- proving blood circulation ( improving microcirculation, extend- ing blood vessels, restoring the function of heart), preventing thrombosis (enhancing antiplatelet effects and anticoagulation, increasing fibrinolytic activity, ameliorating hemokinesis). In a- ddition to injury from knocks and falls and menstrual irregulari- ties, Chinese herbs for activating blood and resolving stasis are also widely and effectively used in other conditions inclu- ding, for example, coronary artery diseases, strokes, and ca- ncers.Didang Tang is well explored and was found to be effecti- ve for various conditions related to blood stagnation. On the b- asis of my professor's experience, we used an optimized for- mula: adding Radix Salviae Miltiorrhizae 20g and Herba Leo- nuri 50g, and removing Eupolyphaga seu Steleophaga. The goal of this study is to prove the effect of Didang Tang on he- morheology, hence its preventing and curative effects on bl- ood stagnation. Objective To investigate if Didang Tang can influence hem- orheology in rats.Methods 60 rats were randomly allocated to one of 6 g- roups treated by sham surgery, surgery, Nimodipine (21mg /k g), Didang Tang (16.2g/kg), Didang Tang (8.1g/kg), Didang Tang (4.05g/kg) respectively. Rats in each group were lavag- ed one time per day for ten consecutive days. On the eleventh day, rats in each group were subcutaneously injected 0.1% Adren aline Hydrochloride (0.1ml/rat) after treatment and then, after 30min, were icebathed for 5min. On the twelfth day, rats in each group were ice-bathed for 5min after treatment. On th- e th irteenth day, rats in each group were subcutaneously inje- cted 0.1% Adrenaline Hydrochloride (0.1ml/rat) 30min after tr- eatment. On the fourteenth day, various indicators associated with hemorheology were tested immediately after 10% trichlo- roethanal belly cavity anesthetization, abdo- minal aorta hae- mos pasia, and heparin anticoagulation.Results Didang Tang can significantly influence various in- dicators associated with hemorheology including blood vis- cosity, plasma viscosity, hematocrit, concentration of fibrinog- en. There were significant differences among these indicators between treatment and control groups, and between before a- nd after treatment; however, compared with Nimodipine group, there was not significant difference.Conclusion This study provided evidence supporting t- hat Didang Tang is effective for activating blood and resolving blood stasis, warranting the clinical use of Didang Tang for bl- ood stagnation.
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