PDTC Inhibiting Experimental Rat's Corneal Neovascularization By Alkali Burn

[Objective]To investigate the anti-angiogenesis effects and possible mechanism of PDTC when administered orally on corneal neovascularization(CNV)in rat induced by alkali burn.We examined the expressions of NF-κB and VEGF on the rat corneal.[Mathods]Following the central cornea of 44 eyes were burned by 1mol/L NaOH,Wistar rat were randomly assigned to blank group(A),control group(B) and treated group(C).Group C was treated with PDTC on 2mg/ml and Group B with PBS,four times daily every rat.Measure the length and clock hour of the blood vessels.Expressions of NF-κB and VEGF were examined on 6h,1d,4d,7d,14d in RT-PCRand then analysis the relation of corneal neovascularization and NF-κB and VEGF.[Result]The cornea area of treated group was statistically smaller than that in the control group.The control groups' result of RT-PCR shows that expressions of NF-κB and VEGF is the highest,and the result of the treated group is between the other groups.[Conclusion]PDTC can inhibit corneal angiogenesis induced by alkaline cauterization of the central cornea.The effect is associated with the inhibition of VEGF by PDTC.